9FQJ
E3 ligase Cbl-b in complex with a carbamate scaffold inhibitor (compound 12)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | E3 ubiquitin-protein ligase CBL-B | polymer | 394 | 45809.5 | 2 | UniProt (Q13191) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) Pfam (PF00097) | Homo sapiens (human) | |
| 2 | C, G (A, B) | 2-cyclopropyl-6-methyl-~{N}-[3-[(6~{S})-6-methyl-2-oxidanylidene-1,3-oxazinan-6-yl]phenyl]pyrimidine-4-carboxamide | non-polymer | 366.4 | 2 | Chemie (A1IE5) | |||
| 3 | D, E, H, I (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | F, J (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 467 | Chemie (HOH) |
Sequence modifications
A, B: 36 - 427 (UniProt: Q13191)
| PDB | External Database | Details |
|---|---|---|
| His 34 | - | expression tag |
| Met 35 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 91619.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1040.4 | |
| All* | Total formula weight | 92659.5 |
