9FQJ
E3 ligase Cbl-b in complex with a carbamate scaffold inhibitor (compound 12)
This is a non-PDB format compatible entry.
Functional Information from PROSITE/UniProt
| site_id | PS00518 |
| Number of Residues | 10 |
| Details | ZF_RING_1 Zinc finger RING-type signature. CgHlMCtsCL |
| Chain | Residue | Details |
| A | CYS388-LEU397 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 78 |
| Details | ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 |
| Chain | Residue | Details |
| A | CYS373-ARG412 | |
| B | CYS373-ARG412 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P22681 |
| Chain | Residue | Details |
| A | ASP221 | |
| B | GLU232 | |
| A | THR223 | |
| A | ASN225 | |
| A | TYR227 | |
| A | GLU232 | |
| B | ASP221 | |
| B | THR223 | |
| B | ASN225 | |
| B | TYR227 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG286 | |
| B | ARG286 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PKC/PRKCQ => ECO:0000269|PubMed:19549985 |
| Chain | Residue | Details |
| A | SER282 | |
| B | SER282 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000305|PubMed:20525694 |
| Chain | Residue | Details |
| A | TYR363 | |
| B | TYR363 |
