9FPX
Crystal structure of DYRK1A in complex with Curcumin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 371 | 43311.8 | 2 | UniProt (Q13627) Pfam (PF00069) | Homo sapiens (human) | Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,MNBH,hMNB |
| 2 | C, E (A, B) | curcumin | non-polymer | 368.4 | 2 | Chemie (CC9) | |||
| 3 | D (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 95 | Chemie (HOH) |
Sequence modifications
A, B: 126 - 489 (UniProt: Q13627)
| PDB | External Database | Details |
|---|---|---|
| Met 125 | - | initiating methionine |
| His 490 | - | expression tag |
| His 491 | - | expression tag |
| His 492 | - | expression tag |
| His 493 | - | expression tag |
| His 494 | - | expression tag |
| His 495 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 86623.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 931.0 | |
| All* | Total formula weight | 87554.5 |
