9FEH
Crystal structure of SARS-CoV-2 nsp14 methyltransferase domain in complex with the STM957 inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Transcription factor ETV6,Guanine-N7 methyltransferase nsp14 | polymer | 308 | 35526.4 | 1 | UniProt (P41212) UniProt (P0DTD1) Pfam (PF02198) Pfam (PF06471) | Severe acute respiratory syndrome coronavirus 2 | ETS translocation variant 6,ETS-related protein Tel1,Tel,Non-structural protein 14,nsp14,Proofreading exoribonuclease nsp14,ExoN |
| 2 | B (A) | ~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-pyridin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-3-cyano-~{N}-ethyl-4-methoxy-benzenesulfonamide | non-polymer | 589.6 | 1 | Chemie (A1IB6) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence modifications
A: 220 - 296 (UniProt: P41212)
A: 300 - 527 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Glu 285 | Val 112 | conflict |
| Pro 297 | - | linker |
| Ala 298 | - | linker |
| Ala 299 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35526.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 655.0 | |
| All* | Total formula weight | 36181.5 |
