9FAS
CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with pregnenolone sulfate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Gamma-aminobutyric acid receptor subunit alpha-1 | polymer | 409 | 46585.6 | 2 | UniProt (P14867) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | GABA(A) receptor subunit alpha-1,GABAAR subunit alpha-1 |
| 2 | B, E (B, E) | Gamma-aminobutyric acid receptor subunit beta-3 | polymer | 441 | 50904.5 | 2 | UniProt (P28472) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | GABA(A) receptor subunit beta-3,GABAAR subunit beta-3 |
| 3 | C (C) | Isoform 1 of Gamma-aminobutyric acid receptor subunit gamma-2 | polymer | 412 | 48123.4 | 1 | UniProt (P18507) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | GABA(A) receptor subunit gamma-2,GABAAR subunit gamma-2 |
| 4 | F (F) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 1 | In PDB GlyTouCan (G40702WU) | |||
| 5 | G, K (G, K) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 6 | H, J (H, J) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 2 | In PDB GlyTouCan (G09724ZC) | |||
| 7 | I (I) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) | |||
| 8 | AA, CB, IA, L, NA... (B, E, C, A, D) | HEXANE | non-polymer | 86.2 | 8 | Chemie (HEX) PubChem (8058) | |||
| 9 | M, MA (A, D) | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 2 | Chemie (PIO) PubChem (16219852) PubChem (49867504) PubChem (53394310) PubChem (52946598) PubChem (124587602) PubChem (131850384) PubChem (132274717) PubChem (73441659) PubChem (99649229) PubChem (9543520) PubChem (136212530) PubChem (136212534) | |||
| 10 | N, OA, R (A, D) | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate | non-polymer | 749.0 | 3 | Chemie (PGW) | |||
| 11 | BA, BB, CA, DA, FA... (B, E, C, A, D) | DECANE | non-polymer | 142.3 | 17 | Chemie (D10) PubChem (15600) | |||
| 12 | EA, KA, S (C, A) | PALMITIC ACID | non-polymer | 256.4 | 3 | Chemie (PLM) | |||
| 13 | LA, U, WA (C, A, D) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) PubChem (312) | |||
| 14 | V (B) | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE | non-polymer | 535.7 | 1 | Chemie (PX2) PubChem (3702281) PubChem (49867542) | |||
| 15 | AB, TA, W, XA, Z (E, D, B) | HEXADECANE | non-polymer | 226.4 | 5 | Chemie (R16) PubChem (11006) | |||
| 16 | GA (C) | Pregnenolone sulfate | non-polymer | 396.5 | 1 | Chemie (A8W) PubChem (20845972) PubChem (44263373) PubChem (53761718) PubChem (57347247) PubChem (162948113) PubChem (4903) PubChem (105074) PubChem (124303475) PubChem (6602452) PubChem (6604147) PubChem (9802139) PubChem (9952629) PubChem (10668470) PubChem (162948114) PubChem (162948115) | |||
| 17 | HA (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 18 | DB, EB, FB, GB, HB (A, B, C, D, E) | water | water | 18.0 | 303 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 243103.7 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 6113.5 | |
| Non-Polymers* | Number of molecules | 44 |
| Total formula weight | 10009.6 | |
| All* | Total formula weight | 259226.8 |
