9FAS
CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with pregnenolone sulfate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Gamma-aminobutyric acid receptor subunit alpha-1 | polymer | 409 | 46585.6 | 2 | UniProt (P14867) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | GABA(A) receptor subunit alpha-1,GABAAR subunit alpha-1 |
| 2 | B, E (B, E) | Gamma-aminobutyric acid receptor subunit beta-3 | polymer | 441 | 50904.5 | 2 | UniProt (P28472) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | GABA(A) receptor subunit beta-3,GABAAR subunit beta-3 |
| 3 | C (C) | Isoform 1 of Gamma-aminobutyric acid receptor subunit gamma-2 | polymer | 412 | 48123.4 | 1 | UniProt (P18507) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | GABA(A) receptor subunit gamma-2,GABAAR subunit gamma-2 |
| 4 | F (F) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 1 | In PDB GlyTouCan (G40702WU) | |||
| 5 | G, K (G, K) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 6 | H, J (H, J) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 2 | In PDB GlyTouCan (G09724ZC) | |||
| 7 | I (I) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) | |||
| 8 | AA, CB, IA, L, NA... (B, E, C, A, D) | HEXANE | non-polymer | 86.2 | 8 | Chemie (HEX) | |||
| 9 | M, MA (A, D) | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 2 | Chemie (PIO) | |||
| 10 | N, OA, R (A, D) | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate | non-polymer | 749.0 | 3 | Chemie (PGW) | |||
| 11 | BA, BB, CA, DA, FA... (B, E, C, A, D) | DECANE | non-polymer | 142.3 | 17 | Chemie (D10) | |||
| 12 | EA, KA, S (C, A) | PALMITIC ACID | non-polymer | 256.4 | 3 | Chemie (PLM) | |||
| 13 | LA, U, WA (C, A, D) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 14 | V (B) | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE | non-polymer | 535.7 | 1 | Chemie (PX2) | |||
| 15 | AB, TA, W, XA, Z (E, D, B) | HEXADECANE | non-polymer | 226.4 | 5 | Chemie (R16) | |||
| 16 | GA (C) | Pregnenolone sulfate | non-polymer | 396.5 | 1 | Chemie (A8W) | |||
| 17 | HA (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 18 | DB, EB, FB, GB, HB (A, B, C, D, E) | water | water | 18.0 | 303 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 243103.7 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 6113.5 | |
| Non-Polymers* | Number of molecules | 44 |
| Total formula weight | 10009.6 | |
| All* | Total formula weight | 259226.8 |
