9F6E
Human DNA polymerase epsilon bound to DNA and PCNA (ajar conformation)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | DNA polymerase epsilon catalytic subunit A | polymer | 1200 | 138137.6 | 1 | UniProt (Q07864) Pfam (PF03104) Pfam (PF22634) In PDB | Homo sapiens (human) | 3'-5' exodeoxyribonuclease,DNA polymerase II subunit A |
2 | B, C, D | Proliferating cell nuclear antigen | polymer | 261 | 28795.8 | 3 | UniProt (P12004) Pfam (PF00705) Pfam (PF02747) In PDB | Homo sapiens (human) | PCNA,Cyclin |
3 | P | DNA nascent strand | polymer | 24 | 7074.6 | 1 | synthetic construct | ||
4 | T | DNA template strand | polymer | 38 | 12033.7 | 1 | synthetic construct | ||
5 | A | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 1 | Chemie (SF4) | |||
6 | A | 2',3'-dideoxyadenosine triphosphate | non-polymer | 475.2 | 1 | Chemie (DDS) |
Sequence modifications
A: 1 - 1200 (UniProt: Q07864)
PDB | External Database | Details |
---|---|---|
Ala 275 | Asp 275 | engineered mutation |
Ala 277 | Glu 277 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 243633.1 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 826.8 | |
All* | Total formula weight | 244460.0 |