9EY2

Human mitochondrial RNase Z with tRNA-His-CCA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	3-hydroxyacyl-CoA dehydrogenase type-2	polymer	261	26947.0	4	UniProt (Q99714) Pfam (PF00106)	Homo sapiens (human)	17-beta-estradiol 17-dehydrogenase,2-methyl-3-hydroxybutyryl-CoA dehydrogenase,MHBD,3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)),3-hydroxy-2-methylbutyryl-CoA dehydrogenase,3-hydroxyacyl-CoA dehydrogenase type II,3alpha(or 20beta)-hydroxysteroid dehydrogenase,7-alpha-hydroxysteroid dehydrogenase,Endoplasmic reticulum-associated amyloid beta-peptide-binding protein,Mitochondrial ribonuclease P protein 2,Mitochondrial RNase P protein 2,Short chain dehydrogenase/reductase family 5C member 1,Short-chain type dehydrogenase/reductase XH98G2,Type II HADH
2	E (F)	tRNA methyltransferase 10 homolog C	polymer	356	42055.3	1	UniProt (Q7L0Y3) Pfam (PF01746)	Homo sapiens (human)	HBV pre-S2 trans-regulated protein 2,Mitochondrial ribonuclease P protein 1,Mitochondrial RNase P protein 1,RNA (guanine-9-)-methyltransferase domain-containing protein 1,Renal carcinoma antigen NY-REN-49,mRNA methyladenosine-N(1)-methyltransferase,tRNA (adenine(9)-N(1))-methyltransferase,tRNA (guanine(9)-N(1))-methyltransferase
3	F (T)	mt-tRNA-His-CCA	polymer	71	22626.5	1	GenBank (1896813685)	Homo sapiens
4	G (E)	Zinc phosphodiesterase ELAC protein 2	polymer	797	89142.3	1	UniProt (Q9BQ52) Pfam (PF13691) Pfam (PF12706)	Homo sapiens (human)	ElaC homolog protein 2,Heredity prostate cancer protein 2,Ribonuclease Z 2,RNase Z 2,tRNA 3 endonuclease 2,tRNase Z 2
5	H (F)	S-ADENOSYLMETHIONINE	non-polymer		398.4	1	Chemie (SAM)
6	I (T)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	1	Chemie (GTP)
7	J, K (E)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

F: 70 - 403 (UniProt: Q7L0Y3)

PDB	External Database	Details
Ala 404	-	expression tag
Glu 405	-	expression tag
Asn 406	-	expression tag
Leu 407	-	expression tag
Tyr 408	-	expression tag
Phe 409	-	expression tag
Gln 410	-	expression tag
Ser 411	-	expression tag
His 412	-	expression tag
His 413	-	expression tag
His 414	-	expression tag
His 415	-	expression tag
His 416	-	expression tag
His 417	-	expression tag
Asp 418	-	expression tag
Tyr 419	-	expression tag
Lys 420	-	expression tag
Asp 421	-	expression tag
Asp 422	-	expression tag
Asp 423	-	expression tag
Asp 424	-	expression tag
Lys 425	-	expression tag

E: 31 - 826 (UniProt: Q9BQ52)

PDB	External Database	Details
Ser 30	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	261612.2
Non-Polymers*	Number of molecules	4
	Total formula weight	1052.4
All*	Total formula weight	262664.6

*Water molecules are not included.