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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9EY2

Human mitochondrial RNase Z with tRNA-His-CCA

Functional Information from GO Data
ChainGOidnamespacecontents
A0000049molecular_functiontRNA binding
A0003723molecular_functionRNA binding
A0003857molecular_function3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
A0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005886cellular_componentplasma membrane
A0006550biological_processL-isoleucine catabolic process
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006635biological_processfatty acid beta-oxidation
A0006699biological_processbile acid biosynthetic process
A0007005biological_processmitochondrion organization
A0008033biological_processtRNA processing
A0008202biological_processsteroid metabolic process
A0008207biological_processC21-steroid hormone metabolic process
A0008209biological_processandrogen metabolic process
A0008210biological_processestrogen metabolic process
A0008709molecular_functioncholate 7-alpha-dehydrogenase (NAD+) activity
A0016491molecular_functionoxidoreductase activity
A0030283molecular_functiontestosterone dehydrogenase [NAD(P)+] activity
A0030678cellular_componentmitochondrial ribonuclease P complex
A0042645cellular_componentmitochondrial nucleoid
A0043527cellular_componenttRNA methyltransferase complex
A0044594molecular_function17-beta-hydroxysteroid dehydrogenase (NAD+) activity
A0047015molecular_function3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
A0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
A0047044molecular_functionandrostan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity
A0051289biological_processprotein homotetramerization
A0062173biological_processbrexanolone metabolic process
A0070901biological_processmitochondrial tRNA methylation
A0097745biological_processmitochondrial tRNA 5'-end processing
A0106281molecular_functionchenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
A0106282molecular_functionisoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
A0106283molecular_functionursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
A1990180biological_processmitochondrial tRNA 3'-end processing
B0000049molecular_functiontRNA binding
B0003723molecular_functionRNA binding
B0003857molecular_function3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
B0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005886cellular_componentplasma membrane
B0006550biological_processL-isoleucine catabolic process
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0006635biological_processfatty acid beta-oxidation
B0006699biological_processbile acid biosynthetic process
B0007005biological_processmitochondrion organization
B0008033biological_processtRNA processing
B0008202biological_processsteroid metabolic process
B0008207biological_processC21-steroid hormone metabolic process
B0008209biological_processandrogen metabolic process
B0008210biological_processestrogen metabolic process
B0008709molecular_functioncholate 7-alpha-dehydrogenase (NAD+) activity
B0016491molecular_functionoxidoreductase activity
B0030283molecular_functiontestosterone dehydrogenase [NAD(P)+] activity
B0030678cellular_componentmitochondrial ribonuclease P complex
B0042645cellular_componentmitochondrial nucleoid
B0043527cellular_componenttRNA methyltransferase complex
B0044594molecular_function17-beta-hydroxysteroid dehydrogenase (NAD+) activity
B0047015molecular_function3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
B0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
B0047044molecular_functionandrostan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity
B0051289biological_processprotein homotetramerization
B0062173biological_processbrexanolone metabolic process
B0070901biological_processmitochondrial tRNA methylation
B0097745biological_processmitochondrial tRNA 5'-end processing
B0106281molecular_functionchenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
B0106282molecular_functionisoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
B0106283molecular_functionursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
B1990180biological_processmitochondrial tRNA 3'-end processing
C0000049molecular_functiontRNA binding
C0003723molecular_functionRNA binding
C0003857molecular_function3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
C0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0005886cellular_componentplasma membrane
C0006550biological_processL-isoleucine catabolic process
C0006629biological_processlipid metabolic process
C0006631biological_processfatty acid metabolic process
C0006635biological_processfatty acid beta-oxidation
C0006699biological_processbile acid biosynthetic process
C0007005biological_processmitochondrion organization
C0008033biological_processtRNA processing
C0008202biological_processsteroid metabolic process
C0008207biological_processC21-steroid hormone metabolic process
C0008209biological_processandrogen metabolic process
C0008210biological_processestrogen metabolic process
C0008709molecular_functioncholate 7-alpha-dehydrogenase (NAD+) activity
C0016491molecular_functionoxidoreductase activity
C0030283molecular_functiontestosterone dehydrogenase [NAD(P)+] activity
C0030678cellular_componentmitochondrial ribonuclease P complex
C0042645cellular_componentmitochondrial nucleoid
C0043527cellular_componenttRNA methyltransferase complex
C0044594molecular_function17-beta-hydroxysteroid dehydrogenase (NAD+) activity
C0047015molecular_function3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
C0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
C0047044molecular_functionandrostan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity
C0051289biological_processprotein homotetramerization
C0062173biological_processbrexanolone metabolic process
C0070901biological_processmitochondrial tRNA methylation
C0097745biological_processmitochondrial tRNA 5'-end processing
C0106281molecular_functionchenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
C0106282molecular_functionisoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
C0106283molecular_functionursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
C1990180biological_processmitochondrial tRNA 3'-end processing
D0000049molecular_functiontRNA binding
D0003723molecular_functionRNA binding
D0003857molecular_function3-hydroxyacyl-CoA dehydrogenase (NAD+) activity
D0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0005886cellular_componentplasma membrane
D0006550biological_processL-isoleucine catabolic process
D0006629biological_processlipid metabolic process
D0006631biological_processfatty acid metabolic process
D0006635biological_processfatty acid beta-oxidation
D0006699biological_processbile acid biosynthetic process
D0007005biological_processmitochondrion organization
D0008033biological_processtRNA processing
D0008202biological_processsteroid metabolic process
D0008207biological_processC21-steroid hormone metabolic process
D0008209biological_processandrogen metabolic process
D0008210biological_processestrogen metabolic process
D0008709molecular_functioncholate 7-alpha-dehydrogenase (NAD+) activity
D0016491molecular_functionoxidoreductase activity
D0030283molecular_functiontestosterone dehydrogenase [NAD(P)+] activity
D0030678cellular_componentmitochondrial ribonuclease P complex
D0042645cellular_componentmitochondrial nucleoid
D0043527cellular_componenttRNA methyltransferase complex
D0044594molecular_function17-beta-hydroxysteroid dehydrogenase (NAD+) activity
D0047015molecular_function3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
D0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
D0047044molecular_functionandrostan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity
D0051289biological_processprotein homotetramerization
D0062173biological_processbrexanolone metabolic process
D0070901biological_processmitochondrial tRNA methylation
D0097745biological_processmitochondrial tRNA 5'-end processing
D0106281molecular_functionchenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
D0106282molecular_functionisoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
D0106283molecular_functionursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
D1990180biological_processmitochondrial tRNA 3'-end processing
E0003723molecular_functionRNA binding
E0004518molecular_functionnuclease activity
E0004519molecular_functionendonuclease activity
E0004521molecular_functionRNA endonuclease activity
E0004549molecular_functiontRNA-specific ribonuclease activity
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005739cellular_componentmitochondrion
E0005759cellular_componentmitochondrial matrix
E0005829cellular_componentcytosol
E0008033biological_processtRNA processing
E0016078biological_processtRNA decay
E0016787molecular_functionhydrolase activity
E0042645cellular_componentmitochondrial nucleoid
E0042780biological_processtRNA 3'-end processing
E0042781molecular_function3'-tRNA processing endoribonuclease activity
E0046872molecular_functionmetal ion binding
E0090646biological_processmitochondrial tRNA processing
E1990180biological_processmitochondrial tRNA 3'-end processing
F0005739cellular_componentmitochondrion
F0008033biological_processtRNA processing
Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. SvaafegqvgQaaYSASKGGIvGMTlPIA
ChainResidueDetails
ASER155-ALA183
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"15087549","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues40
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15342248","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1U7T","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15087549","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"O08756","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues12
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O08756","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues192
DetailsDomain: {"description":"SAM-dependent MTase TRM10-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01012","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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