9EW2
High resolution structure of FZD7 in complex with miniGs protein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GNAS complex locus,Isoform 4 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 248 | 28907.7 | 1 | UniProt (Q5JWD1) UniProt (P63092) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 340 | 37416.9 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (C) | Ggamma | polymer | 96 | 10366.8 | 1 | Pfam (PF00631) UniProt (by SIFTS) (P59768) | Homo sapiens | |
| 4 | D (N) | Nb35 | polymer | 149 | 16054.2 | 1 | Homo sapiens | ||
| 5 | E (R) | Frizzled-7 | polymer | 599 | 67137.6 | 1 | UniProt (O75084) Pfam (PF01392) Pfam (PF01534) | Homo sapiens | Fz-7,hFz7,FzE3 |
Sequence modifications
A: 6 - 64 (UniProt: Q5JWD1)
A: 204 - 394 (UniProt: P63092)
R: 1 - 37 (PDB: 9EW2)
R: 38 - 574 (UniProt: O75084)
| PDB | External Database | Details |
|---|---|---|
| Asp 49 | Gly 49 | conflict |
| Asn 50 | Glu 50 | conflict |
| Gly 196 | - | linker |
| Gly 197 | - | linker |
| Ser 198 | - | linker |
| Gly 199 | - | linker |
| Gly 200 | - | linker |
| Ser 201 | - | linker |
| Gly 202 | - | linker |
| Gly 203 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Asp 249 | Ala 250 | conflict |
| Asp 252 | Ser 253 | conflict |
| - | Asn 255 | deletion |
| - | Met 256 | deletion |
| - | Val 257 | deletion |
| - | Ile 258 | deletion |
| - | Arg 259 | deletion |
| - | Glu 260 | deletion |
| - | Asp 261 | deletion |
| - | Asn 262 | deletion |
| - | Gln 263 | deletion |
| - | Thr 264 | deletion |
| Ala 372 | Ile 373 | conflict |
| Ile 375 | Val 376 | conflict |
R: 38 - 574 (UniProt: O75084)
| PDB | External Database | Details |
|---|---|---|
| His 575 | - | expression tag |
| His 576 | - | expression tag |
| His 577 | - | expression tag |
| His 578 | - | expression tag |
| His 579 | - | expression tag |
| His 580 | - | expression tag |
| His 581 | - | expression tag |
| His 582 | - | expression tag |
| His 583 | - | expression tag |
| His 584 | - | expression tag |
| Gly 585 | - | expression tag |
| Leu 586 | - | expression tag |
| Asn 587 | - | expression tag |
| Asp 588 | - | expression tag |
| Ile 589 | - | expression tag |
| Phe 590 | - | expression tag |
| Glu 591 | - | expression tag |
| Ala 592 | - | expression tag |
| Gln 593 | - | expression tag |
| Lys 594 | - | expression tag |
| Ile 595 | - | expression tag |
| Glu 596 | - | expression tag |
| Trp 597 | - | expression tag |
| His 598 | - | expression tag |
| Glu 599 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 159883.2 | |
| All* | Total formula weight | 159883.2 |
