9EIC
Crystal structure of unbound N-SH2 domain of SHP2 with T42A mutation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 1 of Tyrosine-protein phosphatase non-receptor type 11 | polymer | 109 | 12177.6 | 1 | UniProt (Q06124) Pfam (PF00017) | Homo sapiens (human) | Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,SHP-2,Shp2,SH-PTP3 |
| 2 | B, C, D (A) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 3 | E (A) | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
A: 1 - 106 (UniProt: Q06124)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ala 42 | Thr 42 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 12177.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 284.9 | |
| All* | Total formula weight | 12462.5 |
