9EI0
Human Kv1.3 mutant - G427H with A0194009G09 nanobodies
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F, G, H (A, B, C, D) | Potassium voltage-gated channel subfamily A member 3,Green fluorescent protein | polymer | 856 | 95099.6 | 4 | UniProt (P22001) UniProt (P42212) | Homo sapiens (human) | HGK5,HLK3,HPCN3,Voltage-gated K(+) channel HuKIII,Voltage-gated potassium channel subunit Kv1.3 |
| 2 | B, C, D, E (E, F, G, H) | A0194009G09 nanobody | polymer | 126 | 13849.4 | 4 | Lama glama | ||
| 3 | I, J, K, L (A) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) |
Sequence modifications
A, B, C, D: 1 - 575 (UniProt: P22001)
A, B, C, D: 590 - 826 (UniProt: P42212)
| PDB | External Database | Details |
|---|---|---|
| His 427 | Gly 427 | engineered mutation |
| Ser 576 | - | linker |
| Leu 577 | - | linker |
| Glu 578 | - | linker |
| Val 579 | - | linker |
| Leu 580 | - | linker |
| Phe 581 | - | linker |
| Gln 582 | - | linker |
| Gly 583 | - | linker |
| Pro 584 | - | linker |
| Ala 585 | - | linker |
| Ala 586 | - | linker |
| Ala 587 | - | linker |
| Met 588 | - | linker |
| Val 589 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Leu 634 | Phe 46 | engineered mutation |
| Leu 652 | Phe 64 | engineered mutation |
| Gly 653 | Ser 65 | engineered mutation |
| Leu 656 | Val 68 | engineered mutation |
| Ala 660 | Ser 72 | engineered mutation |
| Thr 741 | Met 153 | engineered mutation |
| Ala 751 | Val 163 | engineered mutation |
| Gly 763 | Ser 175 | engineered mutation |
| Tyr 791 | Thr 203 | engineered mutation |
| Lys 794 | Ala 206 | engineered mutation |
| Leu 819 | His 231 | engineered mutation |
| Ser 827 | - | expression tag |
| Ala 828 | - | expression tag |
| Trp 829 | - | expression tag |
| Ser 830 | - | expression tag |
| His 831 | - | expression tag |
| Pro 832 | - | expression tag |
| Gln 833 | - | expression tag |
| Phe 834 | - | expression tag |
| Glu 835 | - | expression tag |
| Lys 836 | - | expression tag |
| Gly 837 | - | expression tag |
| Gly 838 | - | expression tag |
| Gly 839 | - | expression tag |
| Ser 840 | - | expression tag |
| Gly 841 | - | expression tag |
| Gly 842 | - | expression tag |
| Gly 843 | - | expression tag |
| Ser 844 | - | expression tag |
| Gly 845 | - | expression tag |
| Gly 846 | - | expression tag |
| Gly 847 | - | expression tag |
| Ser 848 | - | expression tag |
| Trp 849 | - | expression tag |
| Ser 850 | - | expression tag |
| His 851 | - | expression tag |
| Pro 852 | - | expression tag |
| Gln 853 | - | expression tag |
| Phe 854 | - | expression tag |
| Glu 855 | - | expression tag |
| Lys 856 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 435796.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 156.4 | |
| All* | Total formula weight | 435952.6 |
