9E7K
Crystal structure of the UCH37 RPN13 DEUBAD complex bound to an inhibitory nanobody in the canonical ubiquitin binding site
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 3 of Ubiquitin carboxyl-terminal hydrolase isozyme L5 | polymer | 328 | 37523.7 | 1 | UniProt (Q9Y5K5) Pfam (PF01088) Pfam (PF18031) | Homo sapiens (human) | UCH-L5,Ubiquitin C-terminal hydrolase UCH37,Ubiquitin thioesterase L5 |
| 2 | B (C) | Nb-cS1 | polymer | 137 | 14970.7 | 1 | Camelidae mixed library | ||
| 3 | C (B) | Proteasomal ubiquitin receptor ADRM1 | polymer | 126 | 12953.7 | 1 | UniProt (Q16186) Pfam (PF16550) | Homo sapiens (human) | 110 kDa cell membrane glycoprotein,Gp110,Adhesion-regulating molecule 1,ARM-1,Proteasome regulatory particle non-ATPase 13,hRpn13,Rpn13 homolog |
| 4 | D, E, F, G (A) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 5 | H, I, J (A, C, B) | water | water | 18.0 | 65 | Chemie (HOH) |
Sequence modifications
B: 269 - 388 (UniProt: Q16186)
| PDB | External Database | Details |
|---|---|---|
| Gly 263 | - | expression tag |
| Pro 264 | - | expression tag |
| Leu 265 | - | expression tag |
| Gly 266 | - | expression tag |
| Ser 267 | - | expression tag |
| Met 268 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 65448.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 141.8 | |
| All* | Total formula weight | 65589.9 |
