9E7K

Crystal structure of the UCH37 RPN13 DEUBAD complex bound to an inhibitory nanobody in the canonical ubiquitin binding site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0000723	biological_process	telomere maintenance
A	0003723	molecular_function	RNA binding
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0004866	molecular_function	endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006275	biological_process	regulation of DNA replication
A	0006281	biological_process	DNA repair
A	0006282	biological_process	regulation of DNA repair
A	0006310	biological_process	DNA recombination
A	0006338	biological_process	chromatin remodeling
A	0006508	biological_process	proteolysis
A	0006974	biological_process	DNA damage response
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0016579	biological_process	protein deubiquitination
A	0016787	molecular_function	hydrolase activity
A	0021670	biological_process	lateral ventricle development
A	0030901	biological_process	midbrain development
A	0031011	cellular_component	Ino80 complex
A	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
A	0033044	biological_process	regulation of chromosome organization
A	0045739	biological_process	positive regulation of DNA repair
A	0045880	biological_process	positive regulation of smoothened signaling pathway
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0045995	biological_process	regulation of embryonic development
A	0048853	biological_process	forebrain morphogenesis
A	0051726	biological_process	regulation of cell cycle
A	0060382	biological_process	regulation of DNA strand elongation
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	0070628	molecular_function	proteasome binding
A	1904507	biological_process	positive regulation of telomere maintenance in response to DNA damage

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Important for enzyme activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9WUP7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---