9E3B
Cryo-EM structure of PRMT5/WDR77 in complex with 6S complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, G, J (A, C, G, J) | Protein arginine N-methyltransferase 5 | polymer | 637 | 72766.7 | 4 | UniProt (O14744) Pfam (PF17285) Pfam (PF05185) Pfam (PF17286) | Homo sapiens (human) | 72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs |
| 2 | B, E, H, K (B, E, H, K) | Methylosome protein WDR77 | polymer | 347 | 37186.7 | 4 | UniProt (Q9BQA1) Pfam (PF00400) | Homo sapiens (human) | Androgen receptor cofactor p44,Methylosome protein 50,MEP-50,WD repeat-containing protein 77,p44/Mep50 |
| 3 | D, F, I, L (D, F, I, L) | Methylosome subunit pICln | polymer | 241 | 26552.5 | 4 | UniProt (P54105) Pfam (PF03517) | Homo sapiens (human) | Chloride channel,nucleotide sensitive 1A,Chloride conductance regulatory protein ICln,I(Cln),Chloride ion current inducer protein,ClCI,Reticulocyte pICln |
| 4 | M, N, O, P (M, N, O, P) | Small nuclear ribonucleoprotein Sm D1 | polymer | 128 | 13954.3 | 4 | UniProt (P62314) Pfam (PF01423) | Homo sapiens (human) | Sm-D1,Sm-D autoantigen,snRNP core protein D1 |
| 5 | Q, R, S, T (A, C, G, J) | SINEFUNGIN | non-polymer | 381.4 | 4 | Chemie (SFG) |
Sequence modifications
B, E, H, K: 1 - 342 (UniProt: Q9BQA1)
D, F, I, L: 1 - 237 (UniProt: P54105)
M, N, O, P: 1 - 119 (UniProt: P62314)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Arg -1 | - | expression tag |
| Thr 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Arg 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 601840.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1525.5 | |
| All* | Total formula weight | 603366.2 |
