9E3B

Cryo-EM structure of PRMT5/WDR77 in complex with 6S complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000387	biological_process	spliceosomal snRNP assembly
A	0000785	cellular_component	chromatin
A	0002039	molecular_function	p53 binding
A	0003714	molecular_function	transcription corepressor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0006351	biological_process	DNA-templated transcription
A	0006353	biological_process	DNA-templated transcription termination
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006479	biological_process	protein methylation
A	0007088	biological_process	regulation of mitotic nuclear division
A	0008168	molecular_function	methyltransferase activity
A	0008327	molecular_function	methyl-CpG binding
A	0010468	biological_process	regulation of gene expression
A	0016274	molecular_function	protein-arginine N-methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0018216	biological_process	peptidyl-arginine methylation
A	0032259	biological_process	methylation
A	0032922	biological_process	circadian regulation of gene expression
A	0032991	cellular_component	protein-containing complex
A	0034709	cellular_component	methylosome
A	0035097	cellular_component	histone methyltransferase complex
A	0035243	molecular_function	protein-arginine omega-N symmetric methyltransferase activity
A	0035246	biological_process	peptidyl-arginine N-methylation
A	0042054	molecular_function	histone methyltransferase activity
A	0042118	biological_process	endothelial cell activation
A	0042802	molecular_function	identical protein binding
A	0043021	molecular_function	ribonucleoprotein complex binding
A	0044020	molecular_function	histone H4R3 methyltransferase activity
A	0044027	biological_process	negative regulation of gene expression via chromosomal CpG island methylation
A	0044877	molecular_function	protein-containing complex binding
A	0045596	biological_process	negative regulation of cell differentiation
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046982	molecular_function	protein heterodimerization activity
A	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
A	0048511	biological_process	rhythmic process
A	0048714	biological_process	positive regulation of oligodendrocyte differentiation
A	0070372	biological_process	regulation of ERK1 and ERK2 cascade
A	0070888	molecular_function	E-box binding
A	0090161	biological_process	Golgi ribbon formation
A	0097421	biological_process	liver regeneration
A	0140938	molecular_function	histone H3 methyltransferase activity
A	1901796	biological_process	regulation of signal transduction by p53 class mediator
A	1904992	biological_process	positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
A	2000234	biological_process	positive regulation of rRNA processing
B	0000209	biological_process	protein polyubiquitination
B	0000387	biological_process	spliceosomal snRNP assembly
B	0003713	molecular_function	transcription coactivator activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0008327	molecular_function	methyl-CpG binding
B	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
B	0034709	cellular_component	methylosome
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
B	1990234	cellular_component	transferase complex
B	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
B	2000234	biological_process	positive regulation of rRNA processing
C	0000387	biological_process	spliceosomal snRNP assembly
C	0000785	cellular_component	chromatin
C	0002039	molecular_function	p53 binding
C	0003714	molecular_function	transcription corepressor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0006325	biological_process	chromatin organization
C	0006338	biological_process	chromatin remodeling
C	0006351	biological_process	DNA-templated transcription
C	0006353	biological_process	DNA-templated transcription termination
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006479	biological_process	protein methylation
C	0007088	biological_process	regulation of mitotic nuclear division
C	0008168	molecular_function	methyltransferase activity
C	0008327	molecular_function	methyl-CpG binding
C	0010468	biological_process	regulation of gene expression
C	0016274	molecular_function	protein-arginine N-methyltransferase activity
C	0016740	molecular_function	transferase activity
C	0018216	biological_process	peptidyl-arginine methylation
C	0032259	biological_process	methylation
C	0032922	biological_process	circadian regulation of gene expression
C	0032991	cellular_component	protein-containing complex
C	0034709	cellular_component	methylosome
C	0035097	cellular_component	histone methyltransferase complex
C	0035243	molecular_function	protein-arginine omega-N symmetric methyltransferase activity
C	0035246	biological_process	peptidyl-arginine N-methylation
C	0042054	molecular_function	histone methyltransferase activity
C	0042118	biological_process	endothelial cell activation
C	0042802	molecular_function	identical protein binding
C	0043021	molecular_function	ribonucleoprotein complex binding
C	0044020	molecular_function	histone H4R3 methyltransferase activity
C	0044027	biological_process	negative regulation of gene expression via chromosomal CpG island methylation
C	0044877	molecular_function	protein-containing complex binding
C	0045596	biological_process	negative regulation of cell differentiation
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0046982	molecular_function	protein heterodimerization activity
C	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
C	0048511	biological_process	rhythmic process
C	0048714	biological_process	positive regulation of oligodendrocyte differentiation
C	0070372	biological_process	regulation of ERK1 and ERK2 cascade
C	0070888	molecular_function	E-box binding
C	0090161	biological_process	Golgi ribbon formation
C	0097421	biological_process	liver regeneration
C	0140938	molecular_function	histone H3 methyltransferase activity
C	1901796	biological_process	regulation of signal transduction by p53 class mediator
C	1904992	biological_process	positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
C	2000234	biological_process	positive regulation of rRNA processing
D	0000387	biological_process	spliceosomal snRNP assembly
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005681	cellular_component	spliceosomal complex
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005886	cellular_component	plasma membrane
D	0006397	biological_process	mRNA processing
D	0006821	biological_process	chloride transport
D	0006884	biological_process	cell volume homeostasis
D	0008380	biological_process	RNA splicing
D	0015630	cellular_component	microtubule cytoskeleton
D	0034709	cellular_component	methylosome
D	0034715	cellular_component	pICln-Sm protein complex
D	0045292	biological_process	mRNA cis splicing, via spliceosome
D	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
E	0000209	biological_process	protein polyubiquitination
E	0000387	biological_process	spliceosomal snRNP assembly
E	0003713	molecular_function	transcription coactivator activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0008327	molecular_function	methyl-CpG binding
E	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
E	0034709	cellular_component	methylosome
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
E	1990234	cellular_component	transferase complex
E	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
E	2000234	biological_process	positive regulation of rRNA processing
F	0000387	biological_process	spliceosomal snRNP assembly
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005681	cellular_component	spliceosomal complex
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005886	cellular_component	plasma membrane
F	0006397	biological_process	mRNA processing
F	0006821	biological_process	chloride transport
F	0006884	biological_process	cell volume homeostasis
F	0008380	biological_process	RNA splicing
F	0015630	cellular_component	microtubule cytoskeleton
F	0034709	cellular_component	methylosome
F	0034715	cellular_component	pICln-Sm protein complex
F	0045292	biological_process	mRNA cis splicing, via spliceosome
F	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
G	0000387	biological_process	spliceosomal snRNP assembly
G	0000785	cellular_component	chromatin
G	0002039	molecular_function	p53 binding
G	0003714	molecular_function	transcription corepressor activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005694	cellular_component	chromosome
G	0005737	cellular_component	cytoplasm
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0006325	biological_process	chromatin organization
G	0006338	biological_process	chromatin remodeling
G	0006351	biological_process	DNA-templated transcription
G	0006353	biological_process	DNA-templated transcription termination
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006479	biological_process	protein methylation
G	0007088	biological_process	regulation of mitotic nuclear division
G	0008168	molecular_function	methyltransferase activity
G	0008327	molecular_function	methyl-CpG binding
G	0010468	biological_process	regulation of gene expression
G	0016274	molecular_function	protein-arginine N-methyltransferase activity
G	0016740	molecular_function	transferase activity
G	0018216	biological_process	peptidyl-arginine methylation
G	0032259	biological_process	methylation
G	0032922	biological_process	circadian regulation of gene expression
G	0032991	cellular_component	protein-containing complex
G	0034709	cellular_component	methylosome
G	0035097	cellular_component	histone methyltransferase complex
G	0035243	molecular_function	protein-arginine omega-N symmetric methyltransferase activity
G	0035246	biological_process	peptidyl-arginine N-methylation
G	0042054	molecular_function	histone methyltransferase activity
G	0042118	biological_process	endothelial cell activation
G	0042802	molecular_function	identical protein binding
G	0043021	molecular_function	ribonucleoprotein complex binding
G	0044020	molecular_function	histone H4R3 methyltransferase activity
G	0044027	biological_process	negative regulation of gene expression via chromosomal CpG island methylation
G	0044877	molecular_function	protein-containing complex binding
G	0045596	biological_process	negative regulation of cell differentiation
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0046982	molecular_function	protein heterodimerization activity
G	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
G	0048511	biological_process	rhythmic process
G	0048714	biological_process	positive regulation of oligodendrocyte differentiation
G	0070372	biological_process	regulation of ERK1 and ERK2 cascade
G	0070888	molecular_function	E-box binding
G	0090161	biological_process	Golgi ribbon formation
G	0097421	biological_process	liver regeneration
G	0140938	molecular_function	histone H3 methyltransferase activity
G	1901796	biological_process	regulation of signal transduction by p53 class mediator
G	1904992	biological_process	positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
G	2000234	biological_process	positive regulation of rRNA processing
H	0000209	biological_process	protein polyubiquitination
H	0000387	biological_process	spliceosomal snRNP assembly
H	0003713	molecular_function	transcription coactivator activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0008327	molecular_function	methyl-CpG binding
H	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
H	0034709	cellular_component	methylosome
H	0045893	biological_process	positive regulation of DNA-templated transcription
H	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
H	1990234	cellular_component	transferase complex
H	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
H	2000234	biological_process	positive regulation of rRNA processing
I	0000387	biological_process	spliceosomal snRNP assembly
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005681	cellular_component	spliceosomal complex
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005886	cellular_component	plasma membrane
I	0006397	biological_process	mRNA processing
I	0006821	biological_process	chloride transport
I	0006884	biological_process	cell volume homeostasis
I	0008380	biological_process	RNA splicing
I	0015630	cellular_component	microtubule cytoskeleton
I	0034709	cellular_component	methylosome
I	0034715	cellular_component	pICln-Sm protein complex
I	0045292	biological_process	mRNA cis splicing, via spliceosome
I	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
J	0000387	biological_process	spliceosomal snRNP assembly
J	0000785	cellular_component	chromatin
J	0002039	molecular_function	p53 binding
J	0003714	molecular_function	transcription corepressor activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005694	cellular_component	chromosome
J	0005737	cellular_component	cytoplasm
J	0005794	cellular_component	Golgi apparatus
J	0005829	cellular_component	cytosol
J	0006325	biological_process	chromatin organization
J	0006338	biological_process	chromatin remodeling
J	0006351	biological_process	DNA-templated transcription
J	0006353	biological_process	DNA-templated transcription termination
J	0006355	biological_process	regulation of DNA-templated transcription
J	0006479	biological_process	protein methylation
J	0007088	biological_process	regulation of mitotic nuclear division
J	0008168	molecular_function	methyltransferase activity
J	0008327	molecular_function	methyl-CpG binding
J	0010468	biological_process	regulation of gene expression
J	0016274	molecular_function	protein-arginine N-methyltransferase activity
J	0016740	molecular_function	transferase activity
J	0018216	biological_process	peptidyl-arginine methylation
J	0032259	biological_process	methylation
J	0032922	biological_process	circadian regulation of gene expression
J	0032991	cellular_component	protein-containing complex
J	0034709	cellular_component	methylosome
J	0035097	cellular_component	histone methyltransferase complex
J	0035243	molecular_function	protein-arginine omega-N symmetric methyltransferase activity
J	0035246	biological_process	peptidyl-arginine N-methylation
J	0042054	molecular_function	histone methyltransferase activity
J	0042118	biological_process	endothelial cell activation
J	0042802	molecular_function	identical protein binding
J	0043021	molecular_function	ribonucleoprotein complex binding
J	0044020	molecular_function	histone H4R3 methyltransferase activity
J	0044027	biological_process	negative regulation of gene expression via chromosomal CpG island methylation
J	0044877	molecular_function	protein-containing complex binding
J	0045596	biological_process	negative regulation of cell differentiation
J	0045892	biological_process	negative regulation of DNA-templated transcription
J	0046982	molecular_function	protein heterodimerization activity
J	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
J	0048511	biological_process	rhythmic process
J	0048714	biological_process	positive regulation of oligodendrocyte differentiation
J	0070372	biological_process	regulation of ERK1 and ERK2 cascade
J	0070888	molecular_function	E-box binding
J	0090161	biological_process	Golgi ribbon formation
J	0097421	biological_process	liver regeneration
J	0140938	molecular_function	histone H3 methyltransferase activity
J	1901796	biological_process	regulation of signal transduction by p53 class mediator
J	1904992	biological_process	positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
J	2000234	biological_process	positive regulation of rRNA processing
K	0000209	biological_process	protein polyubiquitination
K	0000387	biological_process	spliceosomal snRNP assembly
K	0003713	molecular_function	transcription coactivator activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005794	cellular_component	Golgi apparatus
K	0005829	cellular_component	cytosol
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0008327	molecular_function	methyl-CpG binding
K	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
K	0034709	cellular_component	methylosome
K	0045893	biological_process	positive regulation of DNA-templated transcription
K	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
K	1990234	cellular_component	transferase complex
K	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
K	2000234	biological_process	positive regulation of rRNA processing
L	0000387	biological_process	spliceosomal snRNP assembly
L	0003723	molecular_function	RNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005681	cellular_component	spliceosomal complex
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005886	cellular_component	plasma membrane
L	0006397	biological_process	mRNA processing
L	0006821	biological_process	chloride transport
L	0006884	biological_process	cell volume homeostasis
L	0008380	biological_process	RNA splicing
L	0015630	cellular_component	microtubule cytoskeleton
L	0034709	cellular_component	methylosome
L	0034715	cellular_component	pICln-Sm protein complex
L	0045292	biological_process	mRNA cis splicing, via spliceosome
L	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
M	0000243	cellular_component	commitment complex
M	0000244	biological_process	spliceosomal tri-snRNP complex assembly
M	0000245	biological_process	spliceosomal complex assembly
M	0000387	biological_process	spliceosomal snRNP assembly
M	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0003723	molecular_function	RNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005681	cellular_component	spliceosomal complex
M	0005682	cellular_component	U5 snRNP
M	0005684	cellular_component	U2-type spliceosomal complex
M	0005685	cellular_component	U1 snRNP
M	0005686	cellular_component	U2 snRNP
M	0005687	cellular_component	U4 snRNP
M	0005689	cellular_component	U12-type spliceosomal complex
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0006396	biological_process	RNA processing
M	0006397	biological_process	mRNA processing
M	0008380	biological_process	RNA splicing
M	0030532	cellular_component	small nuclear ribonucleoprotein complex
M	0034709	cellular_component	methylosome
M	0034715	cellular_component	pICln-Sm protein complex
M	0034719	cellular_component	SMN-Sm protein complex
M	0036261	biological_process	7-methylguanosine cap hypermethylation
M	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
M	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
M	0071005	cellular_component	U2-type precatalytic spliceosome
M	0071007	cellular_component	U2-type catalytic step 2 spliceosome
M	0071011	cellular_component	precatalytic spliceosome
M	0071013	cellular_component	catalytic step 2 spliceosome
M	0097526	cellular_component	spliceosomal tri-snRNP complex
M	1903241	biological_process	U2-type prespliceosome assembly
M	1990446	molecular_function	U1 snRNP binding
M	1990904	cellular_component	ribonucleoprotein complex
N	0000243	cellular_component	commitment complex
N	0000244	biological_process	spliceosomal tri-snRNP complex assembly
N	0000245	biological_process	spliceosomal complex assembly
N	0000387	biological_process	spliceosomal snRNP assembly
N	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0003723	molecular_function	RNA binding
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005681	cellular_component	spliceosomal complex
N	0005682	cellular_component	U5 snRNP
N	0005684	cellular_component	U2-type spliceosomal complex
N	0005685	cellular_component	U1 snRNP
N	0005686	cellular_component	U2 snRNP
N	0005687	cellular_component	U4 snRNP
N	0005689	cellular_component	U12-type spliceosomal complex
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006396	biological_process	RNA processing
N	0006397	biological_process	mRNA processing
N	0008380	biological_process	RNA splicing
N	0030532	cellular_component	small nuclear ribonucleoprotein complex
N	0034709	cellular_component	methylosome
N	0034715	cellular_component	pICln-Sm protein complex
N	0034719	cellular_component	SMN-Sm protein complex
N	0036261	biological_process	7-methylguanosine cap hypermethylation
N	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
N	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
N	0071005	cellular_component	U2-type precatalytic spliceosome
N	0071007	cellular_component	U2-type catalytic step 2 spliceosome
N	0071011	cellular_component	precatalytic spliceosome
N	0071013	cellular_component	catalytic step 2 spliceosome
N	0097526	cellular_component	spliceosomal tri-snRNP complex
N	1903241	biological_process	U2-type prespliceosome assembly
N	1990446	molecular_function	U1 snRNP binding
N	1990904	cellular_component	ribonucleoprotein complex
O	0000243	cellular_component	commitment complex
O	0000244	biological_process	spliceosomal tri-snRNP complex assembly
O	0000245	biological_process	spliceosomal complex assembly
O	0000387	biological_process	spliceosomal snRNP assembly
O	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005681	cellular_component	spliceosomal complex
O	0005682	cellular_component	U5 snRNP
O	0005684	cellular_component	U2-type spliceosomal complex
O	0005685	cellular_component	U1 snRNP
O	0005686	cellular_component	U2 snRNP
O	0005687	cellular_component	U4 snRNP
O	0005689	cellular_component	U12-type spliceosomal complex
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0006396	biological_process	RNA processing
O	0006397	biological_process	mRNA processing
O	0008380	biological_process	RNA splicing
O	0030532	cellular_component	small nuclear ribonucleoprotein complex
O	0034709	cellular_component	methylosome
O	0034715	cellular_component	pICln-Sm protein complex
O	0034719	cellular_component	SMN-Sm protein complex
O	0036261	biological_process	7-methylguanosine cap hypermethylation
O	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
O	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
O	0071005	cellular_component	U2-type precatalytic spliceosome
O	0071007	cellular_component	U2-type catalytic step 2 spliceosome
O	0071011	cellular_component	precatalytic spliceosome
O	0071013	cellular_component	catalytic step 2 spliceosome
O	0097526	cellular_component	spliceosomal tri-snRNP complex
O	1903241	biological_process	U2-type prespliceosome assembly
O	1990446	molecular_function	U1 snRNP binding
O	1990904	cellular_component	ribonucleoprotein complex
P	0000243	cellular_component	commitment complex
P	0000244	biological_process	spliceosomal tri-snRNP complex assembly
P	0000245	biological_process	spliceosomal complex assembly
P	0000387	biological_process	spliceosomal snRNP assembly
P	0000388	biological_process	spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005681	cellular_component	spliceosomal complex
P	0005682	cellular_component	U5 snRNP
P	0005684	cellular_component	U2-type spliceosomal complex
P	0005685	cellular_component	U1 snRNP
P	0005686	cellular_component	U2 snRNP
P	0005687	cellular_component	U4 snRNP
P	0005689	cellular_component	U12-type spliceosomal complex
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006396	biological_process	RNA processing
P	0006397	biological_process	mRNA processing
P	0008380	biological_process	RNA splicing
P	0030532	cellular_component	small nuclear ribonucleoprotein complex
P	0034709	cellular_component	methylosome
P	0034715	cellular_component	pICln-Sm protein complex
P	0034719	cellular_component	SMN-Sm protein complex
P	0036261	biological_process	7-methylguanosine cap hypermethylation
P	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
P	0048025	biological_process	negative regulation of mRNA splicing, via spliceosome
P	0071005	cellular_component	U2-type precatalytic spliceosome
P	0071007	cellular_component	U2-type catalytic step 2 spliceosome
P	0071011	cellular_component	precatalytic spliceosome
P	0071013	cellular_component	catalytic step 2 spliceosome
P	0097526	cellular_component	spliceosomal tri-snRNP complex
P	1903241	biological_process	U2-type prespliceosome assembly
P	1990446	molecular_function	U1 snRNP binding
P	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. AVSGskDiCIKVWDL

Chain	Residue	Details
B	ALA140-LEU154

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1228
Details	Domain: {"description":"SAM-dependent MTase PRMT-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01015","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1116
Details	Region: {"description":"TIM barrel","evidences":[{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	688
Details	Region: {"description":"Beta barrel","evidences":[{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Region: {"description":"Dimerization","evidences":[{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Site: {"description":"Critical for specifying symmetric addition of methyl groups","evidences":[{"source":"UniProtKB","id":"P46580","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	212
Details	Repeat: {"description":"WD 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	152
Details	Repeat: {"description":"WD 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	156
Details	Repeat: {"description":"WD 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	160
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	164
Details	Repeat: {"description":"WD 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	160
Details	Repeat: {"description":"WD 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU00221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23071334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---