9E30
Discovery of Potent, Highly Selective and Efficacious SMARCA2 Degraders - Compound 13
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Isoform Short of Probable global transcription activator SNF2L2 | polymer | 123 | 14380.5 | 3 | UniProt (P51531) Pfam (PF00439) | Homo sapiens (human) | ATP-dependent helicase SMARCA2,BRG1-associated factor 190B,BAF190B,Protein brahma homolog,hBRM,SNF2-alpha,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 |
| 2 | D, G, J (A, B, C) | (12'S)-4'-chloro-10'-(piperidin-4-yl)-5'H-spiro[cyclohexane-1,7'-indolo[1,2-a]quinazolin]-5'-one | non-polymer | 419.9 | 3 | Chemie (A1A1O) | |||
| 3 | E, H, K, L (A, B, C) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | F, I (A, B) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 5 | M, N, O (A, B, C) | water | water | 18.0 | 274 | Chemie (HOH) |
Sequence modifications
A, B, C: 1373 - 1493 (UniProt: P51531)
| PDB | External Database | Details |
|---|---|---|
| Ser 1371 | - | expression tag |
| Met 1372 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 43141.6 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1639.6 | |
| All* | Total formula weight | 44781.2 |
