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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9E22

Cryo-EM structure of human cytoplasmic dynein-1 bound to LIS1 in the presence of ATP

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Cytoplasmic dynein 1 heavy chain 1polymer4843554126.31UniProt (Q14204)
Pfam (PF08385)
Pfam (PF03028)
Pfam (PF18198)
Pfam (PF18199)
Pfam (PF08393)
Pfam (PF12774)
Pfam (PF17852)
Pfam (PF12775)
Pfam (PF22597)
Pfam (PF12780)
Pfam (PF12777)
Pfam (PF12781)		Homo sapiens (human)Cytoplasmic dynein heavy chain 1,Dynein heavy chain,cytosolic
2B
(E)		Platelet-activating factor acetylhydrolase IB subunit betapolymer41146722.91UniProt (P43034)
Pfam (PF08513)
Pfam (PF00400)		Homo sapiens (human)Lissencephaly-1 protein,LIS-1,PAF acetylhydrolase 45 kDa subunit,PAF-AH 45 kDa subunit,PAF-AH alpha,PAFAH alpha
3C, G
(A)		ADENOSINE-5'-DIPHOSPHATEnon-polymer427.22Chemie (ADP)
4D, F
(A)		ADENOSINE-5'-TRIPHOSPHATEnon-polymer507.22Chemie (ATP)
5E
(A)		MAGNESIUM IONnon-polymer24.31Chemie (MG)
Sequence modifications
A: 2 - 4646 (UniProt: Q14204)
PDBExternal DatabaseDetails
Gly -196-expression tag
Asp -195-expression tag
Tyr -194-expression tag
Asp -193-expression tag
Ile -192-expression tag
Pro -191-expression tag
Thr -190-expression tag
Thr -189-expression tag
Glu -188-expression tag
Asn -187-expression tag
Leu -186-expression tag
Tyr -185-expression tag
Phe -184-expression tag
Gln -183-expression tag
Gly -182-expression tag
Asp -181-expression tag
Lys -180-expression tag
Asp -179-expression tag
Cys -178-expression tag
Glu -177-expression tag
Met -176-expression tag
Lys -175-expression tag
Arg -174-expression tag
Thr -173-expression tag
Thr -172-expression tag
Leu -171-expression tag
Asp -170-expression tag
Ser -169-expression tag
Pro -168-expression tag
Leu -167-expression tag
Gly -166-expression tag
Lys -165-expression tag
Leu -164-expression tag
Glu -163-expression tag
Leu -162-expression tag
Ser -161-expression tag
Gly -160-expression tag
Cys -159-expression tag
Glu -158-expression tag
Gln -157-expression tag
Gly -156-expression tag
Leu -155-expression tag
His -154-expression tag
Arg -153-expression tag
Ile -152-expression tag
Ile -151-expression tag
Phe -150-expression tag
Leu -149-expression tag
Gly -148-expression tag
Lys -147-expression tag
Gly -146-expression tag
Thr -145-expression tag
Ser -144-expression tag
Ala -143-expression tag
Ala -142-expression tag
Asp -141-expression tag
Ala -140-expression tag
Val -139-expression tag
Glu -138-expression tag
Val -137-expression tag
Pro -136-expression tag
Ala -135-expression tag
Pro -134-expression tag
Ala -133-expression tag
Ala -132-expression tag
Val -131-expression tag
Leu -130-expression tag
Gly -129-expression tag
Gly -128-expression tag
Pro -127-expression tag
Glu -126-expression tag
Pro -125-expression tag
Leu -124-expression tag
Met -123-expression tag
Gln -122-expression tag
Ala -121-expression tag
Thr -120-expression tag
Ala -119-expression tag
Trp -118-expression tag
Leu -117-expression tag
Asn -116-expression tag
Ala -115-expression tag
Tyr -114-expression tag
Phe -113-expression tag
His -112-expression tag
Gln -111-expression tag
Pro -110-expression tag
Glu -109-expression tag
Ala -108-expression tag
Ile -107-expression tag
Glu -106-expression tag
Glu -105-expression tag
Phe -104-expression tag
Pro -103-expression tag
Val -102-expression tag
Pro -101-expression tag
Ala -100-expression tag
Leu -99-expression tag
His -98-expression tag
His -97-expression tag
Pro -96-expression tag
Val -95-expression tag
Phe -94-expression tag
Gln -93-expression tag
Gln -92-expression tag
Glu -91-expression tag
Ser -90-expression tag
Phe -89-expression tag
Thr -88-expression tag
Arg -87-expression tag
Gln -86-expression tag
Val -85-expression tag
Leu -84-expression tag
Trp -83-expression tag
Lys -82-expression tag
Leu -81-expression tag
Leu -80-expression tag
Lys -79-expression tag
Val -78-expression tag
Val -77-expression tag
Lys -76-expression tag
Phe -75-expression tag
Gly -74-expression tag
Glu -73-expression tag
Val -72-expression tag
Ile -71-expression tag
Ser -70-expression tag
Tyr -69-expression tag
Ser -68-expression tag
His -67-expression tag
Leu -66-expression tag
Ala -65-expression tag
Ala -64-expression tag
Leu -63-expression tag
Ala -62-expression tag
Gly -61-expression tag
Asn -60-expression tag
Pro -59-expression tag
Ala -58-expression tag
Ala -57-expression tag
Thr -56-expression tag
Ala -55-expression tag
Ala -54-expression tag
Val -53-expression tag
Lys -52-expression tag
Thr -51-expression tag
Ala -50-expression tag
Leu -49-expression tag
Ser -48-expression tag
Gly -47-expression tag
Asn -46-expression tag
Pro -45-expression tag
Val -44-expression tag
Pro -43-expression tag
Ile -42-expression tag
Leu -41-expression tag
Ile -40-expression tag
Pro -39-expression tag
Cys -38-expression tag
His -37-expression tag
Arg -36-expression tag
Val -35-expression tag
Val -34-expression tag
Gln -33-expression tag
Gly -32-expression tag
Asp -31-expression tag
Leu -30-expression tag
Asp -29-expression tag
Val -28-expression tag
Gly -27-expression tag
Gly -26-expression tag
Tyr -25-expression tag
Glu -24-expression tag
Gly -23-expression tag
Gly -22-expression tag
Leu -21-expression tag
Ala -20-expression tag
Val -19-expression tag
Lys -18-expression tag
Glu -17-expression tag
Trp -16-expression tag
Leu -15-expression tag
Leu -14-expression tag
Ala -13-expression tag
His -12-expression tag
Glu -11-expression tag
Gly -10-expression tag
His -9-expression tag
Arg -8-expression tag
Leu -7-expression tag
Gly -6-expression tag
Lys -5-expression tag
Pro -4-expression tag
Gly -3-expression tag
Leu -2-expression tag
Gly -1-expression tag
Gly 0-expression tag
Ser 1-expression tag
E: 2 - 410 (UniProt: P43034)
PDBExternal DatabaseDetails
Gly 0-expression tag
Ser 1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight600849.2
Non-Polymers*Number of molecules5
Total formula weight1893.1
All*Total formula weight602742.2
*Water molecules are not included.

243531

PDB entries from 2025-10-22

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