Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9E22

Cryo-EM structure of human cytoplasmic dynein-1 bound to LIS1 in the presence of ATP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005868	cellular_component	cytoplasmic dynein complex
A	0005874	cellular_component	microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0005938	cellular_component	cell cortex
A	0007052	biological_process	mitotic spindle organization
A	0007097	biological_process	nuclear migration
A	0008090	biological_process	retrograde axonal transport
A	0008569	molecular_function	minus-end-directed microtubule motor activity
A	0016020	cellular_component	membrane
A	0030175	cellular_component	filopodium
A	0030286	cellular_component	dynein complex
A	0031122	biological_process	cytoplasmic microtubule organization
A	0032388	biological_process	positive regulation of intracellular transport
A	0033962	biological_process	P-body assembly
A	0034063	biological_process	stress granule assembly
A	0035578	cellular_component	azurophil granule lumen
A	0042802	molecular_function	identical protein binding
A	0045505	molecular_function	dynein intermediate chain binding
A	0051293	biological_process	establishment of spindle localization
A	0051301	biological_process	cell division
A	0051959	molecular_function	dynein light intermediate chain binding
A	0060236	biological_process	regulation of mitotic spindle organization
A	0070062	cellular_component	extracellular exosome
A	0090235	biological_process	regulation of metaphase plate congression
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
A	1904115	cellular_component	axon cytoplasm
A	1905832	biological_process	positive regulation of spindle assembly
E	0000132	biological_process	establishment of mitotic spindle orientation
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000235	cellular_component	astral microtubule
E	0000776	cellular_component	kinetochore
E	0001667	biological_process	ameboidal-type cell migration
E	0001675	biological_process	acrosome assembly
E	0001764	biological_process	neuron migration
E	0001961	biological_process	positive regulation of cytokine-mediated signaling pathway
E	0005515	molecular_function	protein binding
E	0005635	cellular_component	nuclear envelope
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005871	cellular_component	kinesin complex
E	0005874	cellular_component	microtubule
E	0005875	cellular_component	microtubule associated complex
E	0005881	cellular_component	cytoplasmic microtubule
E	0005938	cellular_component	cell cortex
E	0006629	biological_process	lipid metabolic process
E	0007017	biological_process	microtubule-based process
E	0007097	biological_process	nuclear migration
E	0007254	biological_process	JNK cascade
E	0007268	biological_process	chemical synaptic transmission
E	0007281	biological_process	germ cell development
E	0007399	biological_process	nervous system development
E	0007405	biological_process	neuroblast proliferation
E	0007611	biological_process	learning or memory
E	0008017	molecular_function	microtubule binding
E	0008090	biological_process	retrograde axonal transport
E	0008201	molecular_function	heparin binding
E	0008247	cellular_component	1-alkyl-2-acetylglycerophosphocholine esterase complex
E	0008344	biological_process	adult locomotory behavior
E	0009306	biological_process	protein secretion
E	0010977	biological_process	negative regulation of neuron projection development
E	0015630	cellular_component	microtubule cytoskeleton
E	0016042	biological_process	lipid catabolic process
E	0016477	biological_process	cell migration
E	0017145	biological_process	stem cell division
E	0019226	biological_process	transmission of nerve impulse
E	0021540	biological_process	corpus callosum morphogenesis
E	0021766	biological_process	hippocampus development
E	0021819	biological_process	layer formation in cerebral cortex
E	0021895	biological_process	cerebral cortex neuron differentiation
E	0021987	biological_process	cerebral cortex development
E	0030036	biological_process	actin cytoskeleton organization
E	0030154	biological_process	cell differentiation
E	0030424	cellular_component	axon
E	0030426	cellular_component	growth cone
E	0030900	biological_process	forebrain development
E	0031023	biological_process	microtubule organizing center organization
E	0031252	cellular_component	cell leading edge
E	0031514	cellular_component	motile cilium
E	0031965	cellular_component	nuclear membrane
E	0031982	cellular_component	vesicle
E	0032420	cellular_component	stereocilium
E	0034452	molecular_function	dynactin binding
E	0036035	biological_process	osteoclast development
E	0038026	biological_process	reelin-mediated signaling pathway
E	0040019	biological_process	positive regulation of embryonic development
E	0042249	biological_process	establishment of planar polarity of embryonic epithelium
E	0042802	molecular_function	identical protein binding
E	0043005	cellular_component	neuron projection
E	0043025	cellular_component	neuronal cell body
E	0043274	molecular_function	phospholipase binding
E	0043622	biological_process	cortical microtubule organization
E	0044877	molecular_function	protein-containing complex binding
E	0045505	molecular_function	dynein intermediate chain binding
E	0045773	biological_process	positive regulation of axon extension
E	0045931	biological_process	positive regulation of mitotic cell cycle
E	0046329	biological_process	negative regulation of JNK cascade
E	0046469	biological_process	platelet activating factor metabolic process
E	0046982	molecular_function	protein heterodimerization activity
E	0047496	biological_process	vesicle transport along microtubule
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0048854	biological_process	brain morphogenesis
E	0050804	biological_process	modulation of chemical synaptic transmission
E	0050885	biological_process	neuromuscular process controlling balance
E	0051010	molecular_function	microtubule plus-end binding
E	0051012	biological_process	microtubule sliding
E	0051081	biological_process	nuclear membrane disassembly
E	0051130	biological_process	positive regulation of cellular component organization
E	0051219	molecular_function	phosphoprotein binding
E	0051301	biological_process	cell division
E	0051649	biological_process	establishment of localization in cell
E	0051656	biological_process	establishment of organelle localization
E	0051660	biological_process	establishment of centrosome localization
E	0051661	biological_process	maintenance of centrosome location
E	0060117	biological_process	auditory receptor cell development
E	0061003	biological_process	positive regulation of dendritic spine morphogenesis
E	0070062	cellular_component	extracellular exosome
E	0070507	biological_process	regulation of microtubule cytoskeleton organization
E	0070840	molecular_function	dynein complex binding
E	0090102	biological_process	cochlea development
E	0090176	biological_process	microtubule cytoskeleton organization involved in establishment of planar polarity
E	0090724	cellular_component	central region of growth cone
E	0097225	cellular_component	sperm midpiece
E	0097529	biological_process	myeloid leukocyte migration
E	0098685	cellular_component	Schaffer collateral - CA1 synapse
E	0098978	cellular_component	glutamatergic synapse
E	0099175	biological_process	regulation of postsynapse organization
E	0140650	biological_process	radial glia-guided pyramidal neuron migration
E	1904115	cellular_component	axon cytoplasm
E	1904936	biological_process	interneuron migration

Functional Information from PROSITE/UniProt

site_id	PS00374
Number of Residues	7
Details	MGMT Methylated-DNA--protein-cysteine methyltransferase active site. IPCHRVV

Chain	Residue	Details
A	ILE-40-VAL-34

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS

Chain	Residue	Details
A	ILE2216-SER2226

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LASCsaDmTIKLWDF

Chain	Residue	Details
E	LEU165-PHE179
E	ILE207-VAL221
E	LEU311-VAL325
E	VAL395-CYS409

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	272
Details	Region: {"description":"AAA 2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	21
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	249
Details	Region: {"description":"AAA 3","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	269
Details	Region: {"description":"AAA 4","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	229
Details	Region: {"description":"AAA 5","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	216
Details	Region: {"description":"AAA 6","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	63
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	28
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	41
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	39
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	39
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	39
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	59
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	41
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	32
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	42
Details	Region: {"description":"Interaction with DCX","evidences":[{"source":"PubMed","id":"11001923","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	22
Details	Region: {"description":"Interaction with NDEL1","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)