9E0F
A focus of DNMT tetramer (1) of the cryo-EM structure of human DNMT3A2-DNMT3B3 complex bound to di-nucleosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (V, Z) | Isoform 3 of DNA (cytosine-5)-methyltransferase 3B | polymer | 773 | 86702.4 | 2 | UniProt (Q9UBC3) Pfam (PF00855) Pfam (PF17980) Pfam (PF21255) Pfam (PF00145) | Homo sapiens (human) | Dnmt3b,DNA methyltransferase HsaIIIB,DNA MTase HsaIIIB,M.HsaIIIB |
| 2 | C, D (U, Y) | DNA (cytosine-5)-methyltransferase 3A | polymer | 689 | 77914.7 | 2 | UniProt (Q9Y6K1) Pfam (PF00855) Pfam (PF17980) Pfam (PF21255) Pfam (PF00145) | Homo sapiens (human) | Dnmt3a,DNA methyltransferase HsaIIIA,M.HsaIIIA |
| 3 | E, F, G, H, I... (V, U, Y) | ZINC ION | non-polymer | 65.4 | 9 | Chemie (ZN) PubChem (32051) | |||
| 4 | K, O (U, Y) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) PubChem (439155) |
Sequence modifications
V, Z: -2 - 770 (UniProt: Q9UBC3)
| PDB | External Database | Details |
|---|---|---|
| Lys 391 | - | insertion |
| Asp 392 | - | insertion |
| Tyr 393 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 329234.2 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1357.5 | |
| All* | Total formula weight | 330591.7 |
