9E09

Cryo-EM structure a single nucleosome (2) focus of human DNMT3A2-DNMT3B3 complex bound to di-nucleosome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (M, Q)	Histone H3.2	polymer	135	15303.9	2	UniProt (Q71DI3) Pfam (PF00125)	Homo sapiens (human)	H3-clustered histone 13,H3-clustered histone 14,H3-clustered histone 15,Histone H3/m,Histone H3/o
2	B, F (N, R)	Histone H4	polymer	103	11394.4	2	UniProt (P62805) Pfam (PF15511)	Homo sapiens (human)
3	C, G (O, S)	Histone H2A	polymer	129	13978.2	2	Pfam (PF00125) Pfam (PF16211) UniProt (by SIFTS) (P0C0S8)	Homo sapiens
4	D, H (P, T)	Histone H2B	polymer	123	13655.9	2	Pfam (PF00125) UniProt (by SIFTS) (P06899)	Homo sapiens
5	I (I)	DNA (156-MER)	polymer	156	48421.8	1		Homo sapiens
6	J (J)	DNA (156-MER)	polymer	156	47892.5	1		Homo sapiens
7	K (X)	DNA (cytosine-5)-methyltransferase 3B	polymer	12	1347.6	1	UniProt (Q9UBC3)	Homo sapiens (human)	Dnmt3b,DNA methyltransferase HsaIIIB,DNA MTase HsaIIIB,M.HsaIIIB
8	L (V)	DNA (cytosine-5)-methyltransferase 3B	polymer	11	1234.5	1	UniProt (Q9UBC3)	Homo sapiens (human)	Dnmt3b,DNA methyltransferase HsaIIIB,DNA MTase HsaIIIB,M.HsaIIIB

Sequence modifications

M, Q: 1 - 135 (UniProt: Q71DI3)

PDB	External Database	Details
Ala 102	Gly 103	conflict

X: 736 - 747 (UniProt: Q9UBC3)

PDB	External Database	Details
Ala 739	Gly 822	conflict

V: 736 - 746 (UniProt: Q9UBC3)

PDB	External Database	Details
Ala 739	Gly 822	conflict

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	207561.5
All*	Total formula weight	207561.5

*Water molecules are not included.