9E00

Cryo-EM structure of human DNMT3A2-DNMT3B3 complex bound to di-nucleosome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, I, M (A, E, M, Q)	Histone H3.2	polymer	135	15303.9	4	UniProt (Q71DI3)	Homo sapiens (human)	H3-clustered histone 13,H3-clustered histone 14,H3-clustered histone 15,Histone H3/m,Histone H3/o
2	B, F, J, N (B, F, N, R)	Histone H4	polymer	103	11394.4	4	UniProt (P62805)	Homo sapiens (human)
3	C, G, K, O (C, G, O, S)	Histone H2A	polymer	129	13978.2	4		Homo sapiens
4	D, H, L, P (D, H, P, T)	Histone H2B	polymer	123	13655.9	4		Homo sapiens
5	Q (I)	DNA (321-MER)	polymer	321	99578.2	1		Homo sapiens
6	R (J)	DNA (321-MER)	polymer	321	98701.6	1		Homo sapiens
7	S, T, W, X (V, Z, L, X)	Isoform 3 of DNA (cytosine-5)-methyltransferase 3B	polymer	773	86702.4	4	UniProt (Q9UBC3)	Homo sapiens (human)	Dnmt3b,DNA methyltransferase HsaIIIB,DNA MTase HsaIIIB,M.HsaIIIB
8	U, V, Y, Z (U, Y, W, K)	DNA (cytosine-5)-methyltransferase 3A	polymer	689	77914.7	4	UniProt (Q9Y6K1)	Homo sapiens (human)	Dnmt3a,DNA methyltransferase HsaIIIA,M.HsaIIIA
9	AA, BA, CA, EA, FA... (V, Y, L)	ZINC ION	non-polymer		65.4	9	Chemie (ZN)
10	DA, HA, LA, MA (U, Y, W, K)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	4	Chemie (SAH)

Sequence modifications

A, E, M, Q: 1 - 135 (UniProt: Q71DI3)

PDB	External Database	Details
Ala 102	Gly 103	conflict

V, Z, L, X: -2 - 770 (UniProt: Q9UBC3)

PDB	External Database	Details
Lys 391	-	insertion
Asp 392	-	insertion
Tyr 393	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	26
	Total formula weight	1074078.3
Non-Polymers*	Number of molecules	13
	Total formula weight	2126.3
All*	Total formula weight	1076204.7

*Water molecules are not included.