9DZJ

Human GC-A bound to ANP and 2xREGN5308

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (H, G)	REGN5308 - Heavy chain	polymer	227	24468.4	2		Mus musculus
2	B, D (L, K)	REGN5308 - Light chain	polymer	213	23323.9	2		Mus musculus
3	E, F (A, B)	Atrial natriuretic peptide receptor 1	polymer	1031	115702.8	2	UniProt (P16066)	Homo sapiens (human)	Atrial natriuretic peptide receptor type A,ANP-A,ANPR-A,NPR-A,Guanylate cyclase A,GC-A
4	G (C)	Atrial natriuretic peptide	polymer	28	3087.5	1	UniProt (P01160)	Homo sapiens (human)	ANP,Alpha-atrial natriuretic peptide,Alpha-hANP,Atrial natriuretic factor,ANF,CDD-ANF,CDD-ANP (99-126),Cardionatrin,Pro atrial natriuretic factor 99-126,proANF 99-126
5	H, I, K, M (E, D, I, M)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	4	In PDB GlyTouCan (G15407YE)
6	J, L (F, J)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
7	N, P (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
8	O, Q (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
9	R, S (H, G)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, B: 0 - 1029 (UniProt: P16066)

PDB	External Database	Details
Ala -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	330077.8
Branched	Number of molecules	6
	Total formula weight	3195.0
Non-Polymers*	Number of molecules	4
	Total formula weight	513.3
All*	Total formula weight	333786.1

*Water molecules are not included.