9DWY

Cryo-EM structure of human MCT8 in complex with thyroid hormone T3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Monocarboxylate transporter 8	polymer	573	63329.2	1	UniProt (P36021) Pfam (PF07690)	Homo sapiens (human)	MCT 8,Monocarboxylate transporter 7,MCT 7,Solute carrier family 16 member 2,X-linked PEST-containing transporter
2	B (A)	3,5,3'TRIIODOTHYRONINE	non-polymer		651.0	1	Chemie (T3)

Sequence modifications

A: 1 - 539 (UniProt: P36021)

PDB	External Database	Details
Ala 540	-	expression tag
Ala 541	-	expression tag
Ala 542	-	expression tag
Leu 543	-	expression tag
Glu 544	-	expression tag
Val 545	-	expression tag
Leu 546	-	expression tag
Phe 547	-	expression tag
Gln 548	-	expression tag
Gly 549	-	expression tag
Pro 550	-	expression tag
Gly 551	-	expression tag
Ala 552	-	expression tag
Ala 553	-	expression tag
Glu 554	-	expression tag
Asp 555	-	expression tag
Gln 556	-	expression tag
Val 557	-	expression tag
Asp 558	-	expression tag
Pro 559	-	expression tag
Arg 560	-	expression tag
Leu 561	-	expression tag
Ile 562	-	expression tag
Asp 563	-	expression tag
Gly 564	-	expression tag
Lys 565	-	expression tag
His 566	-	expression tag
His 567	-	expression tag
His 568	-	expression tag
His 569	-	expression tag
His 570	-	expression tag
His 571	-	expression tag
His 572	-	expression tag
His 573	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	63329.2
Non-Polymers*	Number of molecules	1
	Total formula weight	651.0
All*	Total formula weight	63980.2

*Water molecules are not included.