9DUR

Cryo-EM Structure of CRBN:dHTC1:ENL YEATS

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Protein cereblon	polymer	485	55144.6	1	UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226)	Homo sapiens (human)
2	B (C)	Protein ENL	polymer	154	18225.0	1	UniProt (Q03111) Pfam (PF03366)	Homo sapiens (human)	YEATS domain-containing protein 1
3	C (B)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	D (C)	2-[3-[2-[4-[[(5~{S})-1,3-bis(oxidanylidene)-2,7-diazaspiro[4.4]nonan-7-yl]sulfonylamino]piperidin-1-yl]ethylcarbamoyl]phenyl]-~{N}-cyclobutyl-imidazo[1,2-a]pyridine-6-carboxamide	non-polymer		676.8	1	Chemie (A1IQT)

Sequence modifications

B: 1 - 442 (UniProt: Q96SW2)

PDB	External Database	Details
Met -42	-	initiating methionine
Asp -41	-	expression tag
Tyr -40	-	expression tag
Lys -39	-	expression tag
Asp -38	-	expression tag
Asp -37	-	expression tag
Asp -36	-	expression tag
Asp -35	-	expression tag
Lys -34	-	expression tag
Ser -33	-	expression tag
Ala -32	-	expression tag
Val -31	-	expression tag
Asp -30	-	expression tag
Glu -29	-	expression tag
Asn -28	-	expression tag
Leu -27	-	expression tag
Tyr -26	-	expression tag
Phe -25	-	expression tag
Gln -24	-	expression tag
Gly -23	-	expression tag
Gly -22	-	expression tag
Gly -21	-	expression tag
Arg -20	-	expression tag
Gly -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ala -16	-	expression tag
His -15	-	expression tag
Ile -14	-	expression tag
Val -13	-	expression tag
Met -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Ala -9	-	expression tag
Tyr -8	-	expression tag
Lys -7	-	expression tag
Pro -6	-	expression tag
Thr -5	-	expression tag
Lys -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag

C: 1 - 148 (UniProt: Q03111)

PDB	External Database	Details
His 149	-	expression tag
His 150	-	expression tag
His 151	-	expression tag
His 152	-	expression tag
His 153	-	expression tag
His 154	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	73369.6
Non-Polymers*	Number of molecules	2
	Total formula weight	742.2
All*	Total formula weight	74111.8

*Water molecules are not included.