9DTY
Crystal structure of PRT3789 in complex with the bromodomain of human BRM (SMARCA2) and pVHL:ElonginC:ElonginB
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, CA, E, GA, I... (A, E, I, M, Q...) | Isoform Short of Probable global transcription activator SNF2L2 | polymer | 120 | 13991.1 | 10 | UniProt (P51531) Pfam (PF00439) | Homo sapiens (human) | ATP-dependent helicase SMARCA2,BRG1-associated factor 190B,BAF190B,Protein brahma homolog,hBRM,SNF2-alpha,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 |
| 2 | B, DA, F, HA, J... (B, F, J, N, R...) | von Hippel-Lindau disease tumor suppressor | polymer | 161 | 18615.2 | 10 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) | Homo sapiens (human) | Protein G7,pVHL |
| 3 | AA, C, EA, G, IA... (C, G, K, O, S...) | Elongin-C | polymer | 96 | 10843.4 | 10 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC, Elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, Transcription elongation factor B polypeptide 1 |
| 4 | BA, D, FA, H, JA... (D, H, L, P, T...) | Elongin-B | polymer | 104 | 11748.4 | 10 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 5 | AB, CB, DB, OA, QA... (d, h, k, B, F...) | (4R)-4-hydroxy-1-[(2R)-2-(3-{[(2S)-1-{(3R)-3-[(2M,6aS,11S)-2-(2-hydroxyphenyl)-5,6,6a,7,9,10-hexahydro-8H-pyrazino[1',2':4,5]pyrazino[2,3-c]pyridazin-8-yl]pyrrolidin-1-yl}propan-2-yl]oxy}-1,2-oxazol-5-yl)-3-methylbutanoyl]-N-{(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl}-L-prolinamide | non-polymer | 891.1 | 10 | Chemie (A1BB4) | |||
| 6 | BB, PA, VA, XA, ZA (e, C, S, W, a) | CITRIC ACID | non-polymer | 192.1 | 5 | Chemie (CIT) | |||
| 7 | RA (F) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 8 | EB, FB, GB, HB, IB... (B, C, E, F, G...) | water | water | 18.0 | 76 | Chemie (HOH) |
Sequence modifications
A, E, I, M, Q, U, Y, c, g, k: 2 - 120 (UniProt: P51531)
B, F, J, N, R, V, Z, d, h, l: 2 - 161 (UniProt: P40337)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 40 |
| Total formula weight | 551981.6 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 9930.6 | |
| All* | Total formula weight | 561912.2 |
