9DTY

Crystal structure of PRT3789 in complex with the bromodomain of human BRM (SMARCA2) and pVHL:ElonginC:ElonginB

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006338	biological_process	chromatin remodeling
A	0016586	cellular_component	RSC-type complex
b	0006368	biological_process	transcription elongation by RNA polymerase II
b	0030891	cellular_component	VCB complex
b	0070449	cellular_component	elongin complex
c	0006338	biological_process	chromatin remodeling
c	0016586	cellular_component	RSC-type complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0030891	cellular_component	VCB complex
D	0070449	cellular_component	elongin complex
e	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006338	biological_process	chromatin remodeling
E	0016586	cellular_component	RSC-type complex
f	0006368	biological_process	transcription elongation by RNA polymerase II
f	0030891	cellular_component	VCB complex
f	0070449	cellular_component	elongin complex
g	0006338	biological_process	chromatin remodeling
g	0016586	cellular_component	RSC-type complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0006368	biological_process	transcription elongation by RNA polymerase II
H	0030891	cellular_component	VCB complex
H	0070449	cellular_component	elongin complex
i	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0006338	biological_process	chromatin remodeling
I	0016586	cellular_component	RSC-type complex
j	0006368	biological_process	transcription elongation by RNA polymerase II
j	0030891	cellular_component	VCB complex
j	0070449	cellular_component	elongin complex
k	0006338	biological_process	chromatin remodeling
k	0016586	cellular_component	RSC-type complex
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0006368	biological_process	transcription elongation by RNA polymerase II
L	0030891	cellular_component	VCB complex
L	0070449	cellular_component	elongin complex
m	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0006338	biological_process	chromatin remodeling
M	0016586	cellular_component	RSC-type complex
n	0006368	biological_process	transcription elongation by RNA polymerase II
n	0030891	cellular_component	VCB complex
n	0070449	cellular_component	elongin complex
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0006368	biological_process	transcription elongation by RNA polymerase II
P	0030891	cellular_component	VCB complex
P	0070449	cellular_component	elongin complex
Q	0006338	biological_process	chromatin remodeling
Q	0016586	cellular_component	RSC-type complex
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0006368	biological_process	transcription elongation by RNA polymerase II
T	0030891	cellular_component	VCB complex
T	0070449	cellular_component	elongin complex
U	0006338	biological_process	chromatin remodeling
U	0016586	cellular_component	RSC-type complex
W	0006511	biological_process	ubiquitin-dependent protein catabolic process
X	0006368	biological_process	transcription elongation by RNA polymerase II
X	0030891	cellular_component	VCB complex
X	0070449	cellular_component	elongin complex
Y	0006338	biological_process	chromatin remodeling
Y	0016586	cellular_component	RSC-type complex

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. SevFiqlpSrkelp..EYYelIrkpVdfkkIkerirnhk..Yrslgdlekdvml.LchNAqtF

Chain	Residue	Details
A	SER35-PHE92

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39570797","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9E30","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"39570797","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"9E31","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	550
Details	Region: {"description":"Involved in binding to CCT complex"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	90
Details	Region: {"description":"Interaction with Elongin BC complex"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	520
Details	Domain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---