9DQL

human ClpP - Bortezomib - A192E / E196R

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	ATP-dependent Clp protease proteolytic subunit, mitochondrial	polymer	277	30299.1	14	UniProt (Q16740) Pfam (PF00574)	Homo sapiens (human)	Endopeptidase Clp
2	AA, CA, EA, FA, GA... (H, I, J, K, L...)	N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE	non-polymer		384.2	14	Chemie (BO2)
3	BA, DA, HA, KA, P... (H, I, L, N, A...)	CHLORIDE ION	non-polymer		35.5	9	Chemie (CL)

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L, M, N: 1 - 277 (UniProt: Q16740)

PDB	External Database	Details
Glu 192	Ala 192	engineered mutation
Arg 196	Glu 196	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	14
	Total formula weight	424187.9
Non-Polymers*	Number of molecules	23
	Total formula weight	5698.4
All*	Total formula weight	429886.3

*Water molecules are not included.