Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9DQL

human ClpP - Bortezomib - A192E / E196R

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004175	molecular_function	endopeptidase activity
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0009368	cellular_component	endopeptidase Clp complex
A	0016787	molecular_function	hydrolase activity
A	0033619	biological_process	membrane protein proteolysis
A	0035694	biological_process	mitochondrial protein catabolic process
A	0042802	molecular_function	identical protein binding
A	0051117	molecular_function	ATPase binding
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0004175	molecular_function	endopeptidase activity
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0009368	cellular_component	endopeptidase Clp complex
B	0016787	molecular_function	hydrolase activity
B	0033619	biological_process	membrane protein proteolysis
B	0035694	biological_process	mitochondrial protein catabolic process
B	0042802	molecular_function	identical protein binding
B	0051117	molecular_function	ATPase binding
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0004175	molecular_function	endopeptidase activity
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0009368	cellular_component	endopeptidase Clp complex
C	0016787	molecular_function	hydrolase activity
C	0033619	biological_process	membrane protein proteolysis
C	0035694	biological_process	mitochondrial protein catabolic process
C	0042802	molecular_function	identical protein binding
C	0051117	molecular_function	ATPase binding
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0004175	molecular_function	endopeptidase activity
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0009368	cellular_component	endopeptidase Clp complex
D	0016787	molecular_function	hydrolase activity
D	0033619	biological_process	membrane protein proteolysis
D	0035694	biological_process	mitochondrial protein catabolic process
D	0042802	molecular_function	identical protein binding
D	0051117	molecular_function	ATPase binding
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0004175	molecular_function	endopeptidase activity
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0009368	cellular_component	endopeptidase Clp complex
E	0016787	molecular_function	hydrolase activity
E	0033619	biological_process	membrane protein proteolysis
E	0035694	biological_process	mitochondrial protein catabolic process
E	0042802	molecular_function	identical protein binding
E	0051117	molecular_function	ATPase binding
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0004175	molecular_function	endopeptidase activity
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0008233	molecular_function	peptidase activity
F	0008236	molecular_function	serine-type peptidase activity
F	0009368	cellular_component	endopeptidase Clp complex
F	0016787	molecular_function	hydrolase activity
F	0033619	biological_process	membrane protein proteolysis
F	0035694	biological_process	mitochondrial protein catabolic process
F	0042802	molecular_function	identical protein binding
F	0051117	molecular_function	ATPase binding
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0004175	molecular_function	endopeptidase activity
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008233	molecular_function	peptidase activity
G	0008236	molecular_function	serine-type peptidase activity
G	0009368	cellular_component	endopeptidase Clp complex
G	0016787	molecular_function	hydrolase activity
G	0033619	biological_process	membrane protein proteolysis
G	0035694	biological_process	mitochondrial protein catabolic process
G	0042802	molecular_function	identical protein binding
G	0051117	molecular_function	ATPase binding
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0004175	molecular_function	endopeptidase activity
H	0004176	molecular_function	ATP-dependent peptidase activity
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0006508	biological_process	proteolysis
H	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
H	0008233	molecular_function	peptidase activity
H	0008236	molecular_function	serine-type peptidase activity
H	0009368	cellular_component	endopeptidase Clp complex
H	0016787	molecular_function	hydrolase activity
H	0033619	biological_process	membrane protein proteolysis
H	0035694	biological_process	mitochondrial protein catabolic process
H	0042802	molecular_function	identical protein binding
H	0051117	molecular_function	ATPase binding
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0004175	molecular_function	endopeptidase activity
I	0004176	molecular_function	ATP-dependent peptidase activity
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005759	cellular_component	mitochondrial matrix
I	0006508	biological_process	proteolysis
I	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
I	0008233	molecular_function	peptidase activity
I	0008236	molecular_function	serine-type peptidase activity
I	0009368	cellular_component	endopeptidase Clp complex
I	0016787	molecular_function	hydrolase activity
I	0033619	biological_process	membrane protein proteolysis
I	0035694	biological_process	mitochondrial protein catabolic process
I	0042802	molecular_function	identical protein binding
I	0051117	molecular_function	ATPase binding
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0004175	molecular_function	endopeptidase activity
J	0004176	molecular_function	ATP-dependent peptidase activity
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0006508	biological_process	proteolysis
J	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
J	0008233	molecular_function	peptidase activity
J	0008236	molecular_function	serine-type peptidase activity
J	0009368	cellular_component	endopeptidase Clp complex
J	0016787	molecular_function	hydrolase activity
J	0033619	biological_process	membrane protein proteolysis
J	0035694	biological_process	mitochondrial protein catabolic process
J	0042802	molecular_function	identical protein binding
J	0051117	molecular_function	ATPase binding
J	0051603	biological_process	proteolysis involved in protein catabolic process
K	0004175	molecular_function	endopeptidase activity
K	0004176	molecular_function	ATP-dependent peptidase activity
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005515	molecular_function	protein binding
K	0005739	cellular_component	mitochondrion
K	0005759	cellular_component	mitochondrial matrix
K	0006508	biological_process	proteolysis
K	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
K	0008233	molecular_function	peptidase activity
K	0008236	molecular_function	serine-type peptidase activity
K	0009368	cellular_component	endopeptidase Clp complex
K	0016787	molecular_function	hydrolase activity
K	0033619	biological_process	membrane protein proteolysis
K	0035694	biological_process	mitochondrial protein catabolic process
K	0042802	molecular_function	identical protein binding
K	0051117	molecular_function	ATPase binding
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0004175	molecular_function	endopeptidase activity
L	0004176	molecular_function	ATP-dependent peptidase activity
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0006508	biological_process	proteolysis
L	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
L	0008233	molecular_function	peptidase activity
L	0008236	molecular_function	serine-type peptidase activity
L	0009368	cellular_component	endopeptidase Clp complex
L	0016787	molecular_function	hydrolase activity
L	0033619	biological_process	membrane protein proteolysis
L	0035694	biological_process	mitochondrial protein catabolic process
L	0042802	molecular_function	identical protein binding
L	0051117	molecular_function	ATPase binding
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0004175	molecular_function	endopeptidase activity
M	0004176	molecular_function	ATP-dependent peptidase activity
M	0004252	molecular_function	serine-type endopeptidase activity
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005759	cellular_component	mitochondrial matrix
M	0006508	biological_process	proteolysis
M	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
M	0008233	molecular_function	peptidase activity
M	0008236	molecular_function	serine-type peptidase activity
M	0009368	cellular_component	endopeptidase Clp complex
M	0016787	molecular_function	hydrolase activity
M	0033619	biological_process	membrane protein proteolysis
M	0035694	biological_process	mitochondrial protein catabolic process
M	0042802	molecular_function	identical protein binding
M	0051117	molecular_function	ATPase binding
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0004175	molecular_function	endopeptidase activity
N	0004176	molecular_function	ATP-dependent peptidase activity
N	0004252	molecular_function	serine-type endopeptidase activity
N	0005515	molecular_function	protein binding
N	0005739	cellular_component	mitochondrion
N	0005759	cellular_component	mitochondrial matrix
N	0006508	biological_process	proteolysis
N	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
N	0008233	molecular_function	peptidase activity
N	0008236	molecular_function	serine-type peptidase activity
N	0009368	cellular_component	endopeptidase Clp complex
N	0016787	molecular_function	hydrolase activity
N	0033619	biological_process	membrane protein proteolysis
N	0035694	biological_process	mitochondrial protein catabolic process
N	0042802	molecular_function	identical protein binding
N	0051117	molecular_function	ATPase binding
N	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TwcVGqAASMGS

Chain	Residue	Details
A	THR145-SER156

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RhslPnsrIMIHQP

Chain	Residue	Details
A	ARG167-PRO180

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	ACT_SITE: Nucleophile => ECO:0000269\|PubMed:11923310

Chain	Residue	Details
A	SER153
J	SER153
K	SER153
L	SER153
M	SER153
N	SER153
B	SER153
C	SER153
D	SER153
E	SER153
F	SER153
G	SER153
H	SER153
I	SER153

site_id	SWS_FT_FI2
Number of Residues	14
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	HIS178
J	HIS178
K	HIS178
L	HIS178
M	HIS178
N	HIS178
B	HIS178
C	HIS178
D	HIS178
E	HIS178
F	HIS178
G	HIS178
H	HIS178
I	HIS178

site_id	SWS_FT_FI3
Number of Residues	14
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:O88696

Chain	Residue	Details
A	LYS200
J	LYS200
K	LYS200
L	LYS200
M	LYS200
N	LYS200
B	LYS200
C	LYS200
D	LYS200
E	LYS200
F	LYS200
G	LYS200
H	LYS200
I	LYS200

site_id	SWS_FT_FI4
Number of Residues	14
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS211
J	LYS211
K	LYS211
L	LYS211
M	LYS211
N	LYS211
B	LYS211
C	LYS211
D	LYS211
E	LYS211
F	LYS211
G	LYS211
H	LYS211
I	LYS211

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)