9DQ3

Crystal structure of engineered Ipilimumab (mipi.4) Fab in complex with human CTLA-4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (C)	Cytotoxic T-lymphocyte protein 4	polymer	125	13555.4	1	UniProt (P16410) Pfam (PF07686)	Homo sapiens (human)	Cytotoxic T-lymphocyte-associated antigen 4,CTLA-4
2	B (H)	mipi.4 heavy chain	polymer	229	24708.7	1		Homo sapiens (human)
3	C (L)	mipi.4 light chain	polymer	215	23608.2	1		Homo sapiens (human)
4	D, E, F (C, H, L)	water	water		18.0	321	Chemie (HOH)

Sequence modifications

C: 1 - 118 (UniProt: P16410)

PDB	External Database	Details
Gly 119	-	expression tag
His 120	-	expression tag
His 121	-	expression tag
His 122	-	expression tag
His 123	-	expression tag
His 124	-	expression tag
His 125	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	61872.4
All*	Total formula weight	61872.4

*Water molecules are not included.