9DQ3

Crystal structure of engineered Ipilimumab (mipi.4) Fab in complex with human CTLA-4

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0006955	biological_process	immune response
C	0016020	cellular_component	membrane
C	0042129	biological_process	regulation of T cell proliferation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR199-HIS205
L	TYR193-HIS199

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Region: {"description":"Important for interaction with CD80 and CD86","evidences":[{"source":"PubMed","id":"28484017","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11279502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21156796","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11279502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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