9DPI

Cryo-EM structure of SerRS dimer in complex with two SIRT2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (D, F)	Serine--tRNA ligase, cytoplasmic	polymer	514	58863.2	2	UniProt (P49591) Pfam (PF02403) Pfam (PF00587)	Homo sapiens (human)	Seryl-tRNA synthetase,SerRS,Seryl-tRNA(Ser/Sec) synthetase
2	B, D (C, E)	NAD-dependent protein deacetylase sirtuin-2	polymer	389	43233.1	2	UniProt (Q8IXJ6) Pfam (PF02146)	Homo sapiens (human)	NAD-dependent protein defatty-acylase sirtuin-2,Regulatory protein SIR2 homolog 2,SIR2-like protein 2
3	E, F (C, E)	[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE	non-polymer		559.3	2	Chemie (AR6) PubChem (192) PubChem (25113622) PubChem (25113623) PubChem (44415180) PubChem (51051599) PubChem (44144391) PubChem (445794) PubChem (447048) PubChem (89379870) PubChem (33576) PubChem (447165) PubChem (448826) PubChem (91746164) PubChem (9548001) PubChem (9547960) PubChem (122606931) PubChem (122609061) PubChem (10437766) PubChem (174159053) PubChem (140853820) PubChem (146879505) PubChem (162774256) PubChem (162782217) PubChem (163972867) PubChem (173750345) PubChem (173750346) PubChem (175675949)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	204192.6
Non-Polymers*	Number of molecules	2
	Total formula weight	1118.6
All*	Total formula weight	205311.3

*Water molecules are not included.