Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9DPI

Cryo-EM structure of SerRS dimer in complex with two SIRT2

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000183	biological_process	rDNA heterochromatin formation
C	0000781	cellular_component	chromosome, telomeric region
C	0000792	cellular_component	heterochromatin
C	0003682	molecular_function	chromatin binding
C	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
C	0004407	molecular_function	histone deacetylase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005677	cellular_component	chromatin silencing complex
C	0005694	cellular_component	chromosome
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005813	cellular_component	centrosome
C	0005814	cellular_component	centriole
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0006476	biological_process	protein deacetylation
C	0007084	biological_process	mitotic nuclear membrane reassembly
C	0007096	biological_process	regulation of exit from mitosis
C	0008270	molecular_function	zinc ion binding
C	0010507	biological_process	negative regulation of autophagy
C	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
C	0016042	biological_process	lipid catabolic process
C	0017136	molecular_function	histone deacetylase activity, NAD-dependent
C	0021762	biological_process	substantia nigra development
C	0022011	biological_process	myelination in peripheral nervous system
C	0030426	cellular_component	growth cone
C	0030496	cellular_component	midbody
C	0031507	biological_process	heterochromatin formation
C	0031509	biological_process	subtelomeric heterochromatin formation
C	0031641	biological_process	regulation of myelination
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0033010	cellular_component	paranodal junction
C	0033270	cellular_component	paranode region of axon
C	0033558	molecular_function	protein lysine deacetylase activity
C	0034599	biological_process	cellular response to oxidative stress
C	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
C	0034983	biological_process	peptidyl-lysine deacetylation
C	0035035	molecular_function	histone acetyltransferase binding
C	0040029	biological_process	epigenetic regulation of gene expression
C	0042177	biological_process	negative regulation of protein catabolic process
C	0042325	biological_process	regulation of phosphorylation
C	0042826	molecular_function	histone deacetylase binding
C	0042903	molecular_function	tubulin deacetylase activity
C	0043130	molecular_function	ubiquitin binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043204	cellular_component	perikaryon
C	0043209	cellular_component	myelin sheath
C	0043219	cellular_component	lateral loop
C	0043220	cellular_component	Schmidt-Lanterman incisure
C	0043388	biological_process	positive regulation of DNA binding
C	0043687	biological_process	post-translational protein modification
C	0044224	cellular_component	juxtaparanode region of axon
C	0045599	biological_process	negative regulation of fat cell differentiation
C	0045723	biological_process	positive regulation of fatty acid biosynthetic process
C	0045836	biological_process	positive regulation of meiotic nuclear division
C	0045843	biological_process	negative regulation of striated muscle tissue development
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0046890	biological_process	regulation of lipid biosynthetic process
C	0046970	molecular_function	histone H4K16 deacetylase activity, NAD-dependent
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0051093	biological_process	negative regulation of developmental process
C	0051239	biological_process	regulation of multicellular organismal process
C	0051726	biological_process	regulation of cell cycle
C	0051775	biological_process	response to redox state
C	0051781	biological_process	positive regulation of cell division
C	0051987	biological_process	positive regulation of attachment of spindle microtubules to kinetochore
C	0061433	biological_process	cellular response to caloric restriction
C	0070403	molecular_function	NAD+ binding
C	0070446	biological_process	negative regulation of oligodendrocyte progenitor proliferation
C	0071456	biological_process	cellular response to hypoxia
C	0071872	biological_process	cellular response to epinephrine stimulus
C	0072686	cellular_component	mitotic spindle
C	0072687	cellular_component	meiotic spindle
C	0090042	biological_process	tubulin deacetylation
C	0097386	cellular_component	glial cell projection
C	0140219	molecular_function	histone methacryllysine demethacrylase activity
C	0140228	molecular_function	histone benzoyllysine debenzoylase activity
C	0140297	molecular_function	DNA-binding transcription factor binding
C	0140773	molecular_function	NAD-dependent protein demyristoylase activity
C	0140774	molecular_function	NAD-dependent protein depalmitoylase activity
C	0141218	molecular_function	NAD-dependent protein lysine deacylase activity
C	1900119	biological_process	positive regulation of execution phase of apoptosis
C	1900195	biological_process	positive regulation of oocyte maturation
C	1902725	biological_process	negative regulation of satellite cell differentiation
C	1990404	molecular_function	NAD+-protein mono-ADP-ribosyltransferase activity
C	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
D	0000049	molecular_function	tRNA binding
D	0000122	biological_process	negative regulation of transcription by RNA polymerase II
D	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
D	0001514	biological_process	selenocysteine incorporation
D	0002181	biological_process	cytoplasmic translation
D	0004828	molecular_function	serine-tRNA ligase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006400	biological_process	tRNA modification
D	0006412	biological_process	translation
D	0006434	biological_process	seryl-tRNA aminoacylation
D	0016525	biological_process	negative regulation of angiogenesis
D	0019899	molecular_function	enzyme binding
D	0042803	molecular_function	protein homodimerization activity
D	0060090	molecular_function	molecular adaptor activity
D	0070062	cellular_component	extracellular exosome
D	0098619	molecular_function	selenocysteine-tRNA ligase activity
D	0106217	biological_process	tRNA C3-cytosine methylation
D	1904046	biological_process	negative regulation of vascular endothelial growth factor production
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000183	biological_process	rDNA heterochromatin formation
E	0000781	cellular_component	chromosome, telomeric region
E	0000792	cellular_component	heterochromatin
E	0003682	molecular_function	chromatin binding
E	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
E	0004407	molecular_function	histone deacetylase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005677	cellular_component	chromatin silencing complex
E	0005694	cellular_component	chromosome
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005813	cellular_component	centrosome
E	0005814	cellular_component	centriole
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0006476	biological_process	protein deacetylation
E	0007084	biological_process	mitotic nuclear membrane reassembly
E	0007096	biological_process	regulation of exit from mitosis
E	0008270	molecular_function	zinc ion binding
E	0010507	biological_process	negative regulation of autophagy
E	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
E	0016042	biological_process	lipid catabolic process
E	0017136	molecular_function	histone deacetylase activity, NAD-dependent
E	0021762	biological_process	substantia nigra development
E	0022011	biological_process	myelination in peripheral nervous system
E	0030426	cellular_component	growth cone
E	0030496	cellular_component	midbody
E	0031507	biological_process	heterochromatin formation
E	0031509	biological_process	subtelomeric heterochromatin formation
E	0031641	biological_process	regulation of myelination
E	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
E	0033010	cellular_component	paranodal junction
E	0033270	cellular_component	paranode region of axon
E	0033558	molecular_function	protein lysine deacetylase activity
E	0034599	biological_process	cellular response to oxidative stress
E	0034979	molecular_function	NAD-dependent protein lysine deacetylase activity
E	0034983	biological_process	peptidyl-lysine deacetylation
E	0035035	molecular_function	histone acetyltransferase binding
E	0040029	biological_process	epigenetic regulation of gene expression
E	0042177	biological_process	negative regulation of protein catabolic process
E	0042325	biological_process	regulation of phosphorylation
E	0042826	molecular_function	histone deacetylase binding
E	0042903	molecular_function	tubulin deacetylase activity
E	0043130	molecular_function	ubiquitin binding
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0043204	cellular_component	perikaryon
E	0043209	cellular_component	myelin sheath
E	0043219	cellular_component	lateral loop
E	0043220	cellular_component	Schmidt-Lanterman incisure
E	0043388	biological_process	positive regulation of DNA binding
E	0043687	biological_process	post-translational protein modification
E	0044224	cellular_component	juxtaparanode region of axon
E	0045599	biological_process	negative regulation of fat cell differentiation
E	0045723	biological_process	positive regulation of fatty acid biosynthetic process
E	0045836	biological_process	positive regulation of meiotic nuclear division
E	0045843	biological_process	negative regulation of striated muscle tissue development
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046890	biological_process	regulation of lipid biosynthetic process
E	0046970	molecular_function	histone H4K16 deacetylase activity, NAD-dependent
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0051093	biological_process	negative regulation of developmental process
E	0051239	biological_process	regulation of multicellular organismal process
E	0051726	biological_process	regulation of cell cycle
E	0051775	biological_process	response to redox state
E	0051781	biological_process	positive regulation of cell division
E	0051987	biological_process	positive regulation of attachment of spindle microtubules to kinetochore
E	0061433	biological_process	cellular response to caloric restriction
E	0070403	molecular_function	NAD+ binding
E	0070446	biological_process	negative regulation of oligodendrocyte progenitor proliferation
E	0071456	biological_process	cellular response to hypoxia
E	0071872	biological_process	cellular response to epinephrine stimulus
E	0072686	cellular_component	mitotic spindle
E	0072687	cellular_component	meiotic spindle
E	0090042	biological_process	tubulin deacetylation
E	0097386	cellular_component	glial cell projection
E	0140219	molecular_function	histone methacryllysine demethacrylase activity
E	0140228	molecular_function	histone benzoyllysine debenzoylase activity
E	0140297	molecular_function	DNA-binding transcription factor binding
E	0140773	molecular_function	NAD-dependent protein demyristoylase activity
E	0140774	molecular_function	NAD-dependent protein depalmitoylase activity
E	0141218	molecular_function	NAD-dependent protein lysine deacylase activity
E	1900119	biological_process	positive regulation of execution phase of apoptosis
E	1900195	biological_process	positive regulation of oocyte maturation
E	1902725	biological_process	negative regulation of satellite cell differentiation
E	1990404	molecular_function	NAD+-protein mono-ADP-ribosyltransferase activity
E	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
F	0000049	molecular_function	tRNA binding
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
F	0001514	biological_process	selenocysteine incorporation
F	0002181	biological_process	cytoplasmic translation
F	0004828	molecular_function	serine-tRNA ligase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006400	biological_process	tRNA modification
F	0006412	biological_process	translation
F	0006434	biological_process	seryl-tRNA aminoacylation
F	0016525	biological_process	negative regulation of angiogenesis
F	0019899	molecular_function	enzyme binding
F	0042803	molecular_function	protein homodimerization activity
F	0060090	molecular_function	molecular adaptor activity
F	0070062	cellular_component	extracellular exosome
F	0098619	molecular_function	selenocysteine-tRNA ligase activity
F	0106217	biological_process	tRNA C3-cytosine methylation
F	1904046	biological_process	negative regulation of vascular endothelial growth factor production

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24095058","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4L87","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24095058","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26433229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4L87","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Important for serine binding","evidences":[{"source":"PubMed","id":"28236339","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25672491","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RMG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11427894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23454361","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24389023","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25672491","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25704306","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R8M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q5RJQ4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)