9DP4
APE1 N174Q Product Complex with Abasic DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA repair nuclease/redox regulator APEX1 | polymer | 276 | 31170.5 | 2 | UniProt (P27695) Pfam (PF03372) | Homo sapiens (human) | APEX nuclease,APEN,Apurinic-apyrimidinic endonuclease 1,AP endonuclease 1,APE-1,DNA-(apurinic or apyrimidinic site) endonuclease,Redox factor-1,REF-1 |
| 2 | C, F (D, G) | DNA (5'-D(P*(3DR)P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3') | polymer | 11 | 3210.1 | 2 | synthetic construct | ||
| 3 | D, G (E, H) | DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3') | polymer | 10 | 3061.0 | 2 | synthetic construct | ||
| 4 | E, H (F, I) | DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3') | polymer | 21 | 6465.2 | 2 | synthetic construct | ||
| 5 | I, K (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 6 | J, L (B, D) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 7 | M, N, O, P, Q... (A, B, D, E, F...) | water | water | 18.0 | 249 | Chemie (HOH) |
Sequence modifications
A, B: 43 - 318 (UniProt: P27695)
| PDB | External Database | Details |
|---|---|---|
| Ala 138 | Cys 138 | engineered mutation |
| Gln 174 | Asn 174 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 87813.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 260.9 | |
| All* | Total formula weight | 88074.4 |
