9DF3
EGFR Exon20 insertion mutant SVD bound with (S)-3-((3-chloro-2-methoxyphenyl)amino)-2-(3-((tetrahydrofuran-2-yl)methoxy)pyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 333 | 37864.7 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | 3-[(3-chloranyl-2-methoxy-phenyl)amino]-2-[3-[[(2S)-oxolan-2-yl]methoxy]pyridin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one | non-polymer | 468.9 | 1 | Chemie (A1IMS) | |||
| 3 | C, D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | E, F, G, H, I... (A) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 5 | K (A) | water | water | 18.0 | 211 | Chemie (HOH) |
Sequence modifications
A: 696 - 1025 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 693 | - | expression tag |
| Gly 694 | - | expression tag |
| Ser 695 | - | expression tag |
| Ser 768 | - | insertion |
| Val 769 | - | insertion |
| Asp 770 | - | insertion |
| Arg 951 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37864.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1145.6 | |
| All* | Total formula weight | 39010.3 |
