9DET
Human V-ATPase Vo subcomplex (containing subunit isoform a4) bound to nanobody and inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (e) | V-type proton ATPase subunit e 1 | polymer | 81 | 9380.3 | 1 | UniProt (O15342) Pfam (PF05493) | Homo sapiens (human) | V-ATPase subunit e 1,V-ATPase 9.2 kDa membrane accessory protein,V-ATPase M9.2 subunit,Vacuolar proton pump subunit e 1 |
| 2 | B (f) | Ribonuclease kappa | polymer | 137 | 15435.2 | 1 | UniProt (Q6P5S7) | Homo sapiens (human) | RNase kappa |
| 3 | C (o) | V-type proton ATPase subunit S1 | polymer | 470 | 52067.5 | 1 | UniProt (Q15904) Pfam (PF05827) Pfam (PF20520) | Homo sapiens (human) | V-ATPase subunit S1,Protein XAP-3,V-ATPase Ac45 subunit,V-ATPase S1 accessory protein,Vacuolar proton pump subunit S1 |
| 4 | D (p) | Renin receptor | polymer | 350 | 39045.9 | 1 | UniProt (O75787) Pfam (PF07850) | Homo sapiens (human) | ATPase H(+)-transporting lysosomal accessory protein 2,ATPase H(+)-transporting lysosomal-interacting protein 2,ER-localized type I transmembrane adapter,Embryonic liver differentiation factor 10,N14F,Renin/prorenin receptor,Vacuolar ATP synthase membrane sector-associated protein M8-9,V-ATPase M8.9 subunit |
| 5 | E (b) | V-type proton ATPase 21 kDa proteolipid subunit | polymer | 205 | 21418.2 | 1 | UniProt (Q99437) Pfam (PF00137) | Homo sapiens (human) | V-ATPase 21 kDa proteolipid subunit,Vacuolar proton pump 21 kDa proteolipid subunit,hATPL |
| 6 | F, G, H, I, J... (c, g, h, i, j...) | V-type proton ATPase 16 kDa proteolipid subunit | polymer | 155 | 15743.7 | 9 | UniProt (P27449) Pfam (PF00137) | Homo sapiens (human) | V-ATPase 16 kDa proteolipid subunit,Vacuolar proton pump 16 kDa proteolipid subunit |
| 7 | O (d) | V-type proton ATPase subunit d 1 | polymer | 351 | 40369.9 | 1 | UniProt (P61421) Pfam (PF01992) | Homo sapiens (human) | V-ATPase subunit d 1,32 kDa accessory protein,V-ATPase 40 kDa accessory protein,V-ATPase AC39 subunit,p39,Vacuolar proton pump subunit d 1 |
| 8 | P (a) | V-type proton ATPase 116 kDa subunit a 4 | polymer | 863 | 99168.2 | 1 | UniProt (Q9HBG4) Pfam (PF01496) | Homo sapiens (human) | V-ATPase 116 kDa isoform a 4,Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4,Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform |
| 9 | Q (q) | Anti V-ATPase Nanobody 2CAS66 | polymer | 139 | 15142.9 | 1 | Lama glama | ||
| 10 | JA, LA, MA, R, S... (a, o) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 11 | W (p) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
| 12 | X, Y, Z (p, b) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 3 | Chemie (POV) | |||
| 13 | AA, BA, CA, DA, EA... (c, g, h, i, j...) | Cladoniamide A | non-polymer | 437.8 | 9 | Chemie (A1A4Q) | |||
| 14 | KA (a) | methyl (3R,6Z,10E,14E)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraen-1-yl dihydrogen diphosphate | non-polymer | 534.6 | 1 | Chemie (WJP) |
Sequence modifications
a: 1 - 840 (UniProt: Q9HBG4)
| PDB | External Database | Details |
|---|---|---|
| Gly 841 | - | expression tag |
| Asp 842 | - | expression tag |
| Leu 843 | - | expression tag |
| Asp 844 | - | expression tag |
| Tyr 845 | - | expression tag |
| Lys 846 | - | expression tag |
| Asp 847 | - | expression tag |
| Asp 848 | - | expression tag |
| Asp 849 | - | expression tag |
| Asp 850 | - | expression tag |
| Lys 851 | - | expression tag |
| Leu 852 | - | expression tag |
| Asp 853 | - | expression tag |
| Tyr 854 | - | expression tag |
| Lys 855 | - | expression tag |
| Asp 856 | - | expression tag |
| Asp 857 | - | expression tag |
| Asp 858 | - | expression tag |
| Asp 859 | - | expression tag |
| Lys 860 | - | expression tag |
| Ala 861 | - | expression tag |
| Asp 862 | - | expression tag |
| Leu 863 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 17 |
| Total formula weight | 433721.0 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 8911.6 | |
| All* | Total formula weight | 442632.7 |
