9DET

Human V-ATPase Vo subcomplex (containing subunit isoform a4) bound to nanobody and inhibitor

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
a	0001503	biological_process	ossification
a	0005515	molecular_function	protein binding
a	0005765	cellular_component	lysosomal membrane
a	0005768	cellular_component	endosome
a	0005886	cellular_component	plasma membrane
a	0005903	cellular_component	brush border
a	0006885	biological_process	regulation of pH
a	0007035	biological_process	vacuolar acidification
a	0007605	biological_process	sensory perception of sound
a	0010008	cellular_component	endosome membrane
a	0016323	cellular_component	basolateral plasma membrane
a	0016324	cellular_component	apical plasma membrane
a	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
a	0030670	cellular_component	phagocytic vesicle membrane
a	0030672	cellular_component	synaptic vesicle membrane
a	0031526	cellular_component	brush border membrane
a	0033176	cellular_component	proton-transporting V-type ATPase complex
a	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
a	0045177	cellular_component	apical part of cell
a	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
a	0051117	molecular_function	ATPase binding
a	0051452	biological_process	intracellular pH reduction
a	0070062	cellular_component	extracellular exosome
a	0097254	biological_process	renal tubular secretion
a	0097401	biological_process	synaptic vesicle lumen acidification
a	1902600	biological_process	proton transmembrane transport
b	0000139	cellular_component	Golgi membrane
b	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
b	0005515	molecular_function	protein binding
b	0005765	cellular_component	lysosomal membrane
b	0005768	cellular_component	endosome
b	0005886	cellular_component	plasma membrane
b	0007035	biological_process	vacuolar acidification
b	0007042	biological_process	lysosomal lumen acidification
b	0010008	cellular_component	endosome membrane
b	0015078	molecular_function	proton transmembrane transporter activity
b	0016020	cellular_component	membrane
b	0016241	biological_process	regulation of macroautophagy
b	0030665	cellular_component	clathrin-coated vesicle membrane
b	0030670	cellular_component	phagocytic vesicle membrane
b	0033176	cellular_component	proton-transporting V-type ATPase complex
b	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
b	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
b	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
b	0048388	biological_process	endosomal lumen acidification
b	0051452	biological_process	intracellular pH reduction
b	0061795	biological_process	Golgi lumen acidification
b	1902600	biological_process	proton transmembrane transport
c	0000139	cellular_component	Golgi membrane
c	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
c	0005515	molecular_function	protein binding
c	0005765	cellular_component	lysosomal membrane
c	0005886	cellular_component	plasma membrane
c	0005925	cellular_component	focal adhesion
c	0007035	biological_process	vacuolar acidification
c	0007042	biological_process	lysosomal lumen acidification
c	0010008	cellular_component	endosome membrane
c	0015078	molecular_function	proton transmembrane transporter activity
c	0015986	biological_process	proton motive force-driven ATP synthesis
c	0016020	cellular_component	membrane
c	0016241	biological_process	regulation of macroautophagy
c	0030177	biological_process	positive regulation of Wnt signaling pathway
c	0030665	cellular_component	clathrin-coated vesicle membrane
c	0030670	cellular_component	phagocytic vesicle membrane
c	0030672	cellular_component	synaptic vesicle membrane
c	0031625	molecular_function	ubiquitin protein ligase binding
c	0033176	cellular_component	proton-transporting V-type ATPase complex
c	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
c	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
c	0035577	cellular_component	azurophil granule membrane
c	0046611	cellular_component	lysosomal proton-transporting V-type ATPase complex
c	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
c	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
c	0048388	biological_process	endosomal lumen acidification
c	0051452	biological_process	intracellular pH reduction
c	0061795	biological_process	Golgi lumen acidification
c	0070062	cellular_component	extracellular exosome
c	0070821	cellular_component	tertiary granule membrane
c	0071230	biological_process	cellular response to amino acid stimulus
c	0097401	biological_process	synaptic vesicle lumen acidification
c	0098588	cellular_component	bounding membrane of organelle
c	0101003	cellular_component	ficolin-1-rich granule membrane
c	0160124	molecular_function	guanyl nucleotide exchange factor activator activity
c	1902600	biological_process	proton transmembrane transport
c	1904263	biological_process	positive regulation of TORC1 signaling
d	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
d	0005515	molecular_function	protein binding
d	0005765	cellular_component	lysosomal membrane
d	0005769	cellular_component	early endosome
d	0005813	cellular_component	centrosome
d	0006879	biological_process	intracellular iron ion homeostasis
d	0007034	biological_process	vacuolar transport
d	0007035	biological_process	vacuolar acidification
d	0010008	cellular_component	endosome membrane
d	0015078	molecular_function	proton transmembrane transporter activity
d	0016020	cellular_component	membrane
d	0016241	biological_process	regulation of macroautophagy
d	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
d	0030665	cellular_component	clathrin-coated vesicle membrane
d	0030670	cellular_component	phagocytic vesicle membrane
d	0033176	cellular_component	proton-transporting V-type ATPase complex
d	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
d	0033181	cellular_component	plasma membrane proton-transporting V-type ATPase complex
d	0036295	biological_process	cellular response to increased oxygen levels
d	0042592	biological_process	homeostatic process
d	0046611	cellular_component	lysosomal proton-transporting V-type ATPase complex
d	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
d	0060271	biological_process	cilium assembly
d	0070062	cellular_component	extracellular exosome
d	0071230	biological_process	cellular response to amino acid stimulus
d	0097401	biological_process	synaptic vesicle lumen acidification
d	0098793	cellular_component	presynapse
d	0160124	molecular_function	guanyl nucleotide exchange factor activator activity
d	1902600	biological_process	proton transmembrane transport
d	1904263	biological_process	positive regulation of TORC1 signaling
e	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
e	0005515	molecular_function	protein binding
e	0005765	cellular_component	lysosomal membrane
e	0007035	biological_process	vacuolar acidification
e	0010008	cellular_component	endosome membrane
e	0016020	cellular_component	membrane
e	0016241	biological_process	regulation of macroautophagy
e	0030670	cellular_component	phagocytic vesicle membrane
e	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
e	0042625	molecular_function	ATPase-coupled ion transmembrane transporter activity
e	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
e	1902600	biological_process	proton transmembrane transport
f	0000139	cellular_component	Golgi membrane
f	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
f	0004521	molecular_function	RNA endonuclease activity
f	0005515	molecular_function	protein binding
f	0005765	cellular_component	lysosomal membrane
f	0005886	cellular_component	plasma membrane
f	0006898	biological_process	receptor-mediated endocytosis
f	0007035	biological_process	vacuolar acidification
f	0007042	biological_process	lysosomal lumen acidification
f	0010008	cellular_component	endosome membrane
f	0012505	cellular_component	endomembrane system
f	0016020	cellular_component	membrane
f	0019065	biological_process	receptor-mediated endocytosis of virus by host cell
f	0030665	cellular_component	clathrin-coated vesicle membrane
f	0033176	cellular_component	proton-transporting V-type ATPase complex
f	0048388	biological_process	endosomal lumen acidification
f	0051452	biological_process	intracellular pH reduction
f	0061795	biological_process	Golgi lumen acidification
f	0090304	biological_process	nucleic acid metabolic process
f	1902600	biological_process	proton transmembrane transport
g	0000139	cellular_component	Golgi membrane
g	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
g	0005515	molecular_function	protein binding
g	0005765	cellular_component	lysosomal membrane
g	0005886	cellular_component	plasma membrane
g	0005925	cellular_component	focal adhesion
g	0007035	biological_process	vacuolar acidification
g	0007042	biological_process	lysosomal lumen acidification
g	0010008	cellular_component	endosome membrane
g	0015078	molecular_function	proton transmembrane transporter activity
g	0015986	biological_process	proton motive force-driven ATP synthesis
g	0016020	cellular_component	membrane
g	0016241	biological_process	regulation of macroautophagy
g	0030177	biological_process	positive regulation of Wnt signaling pathway
g	0030665	cellular_component	clathrin-coated vesicle membrane
g	0030670	cellular_component	phagocytic vesicle membrane
g	0030672	cellular_component	synaptic vesicle membrane
g	0031625	molecular_function	ubiquitin protein ligase binding
g	0033176	cellular_component	proton-transporting V-type ATPase complex
g	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
g	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
g	0035577	cellular_component	azurophil granule membrane
g	0046611	cellular_component	lysosomal proton-transporting V-type ATPase complex
g	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
g	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
g	0048388	biological_process	endosomal lumen acidification
g	0051452	biological_process	intracellular pH reduction
g	0061795	biological_process	Golgi lumen acidification
g	0070062	cellular_component	extracellular exosome
g	0070821	cellular_component	tertiary granule membrane
g	0071230	biological_process	cellular response to amino acid stimulus
g	0097401	biological_process	synaptic vesicle lumen acidification
g	0098588	cellular_component	bounding membrane of organelle
g	0101003	cellular_component	ficolin-1-rich granule membrane
g	0160124	molecular_function	guanyl nucleotide exchange factor activator activity
g	1902600	biological_process	proton transmembrane transport
g	1904263	biological_process	positive regulation of TORC1 signaling
h	0000139	cellular_component	Golgi membrane
h	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
h	0005515	molecular_function	protein binding
h	0005765	cellular_component	lysosomal membrane
h	0005886	cellular_component	plasma membrane
h	0005925	cellular_component	focal adhesion
h	0007035	biological_process	vacuolar acidification
h	0007042	biological_process	lysosomal lumen acidification
h	0010008	cellular_component	endosome membrane
h	0015078	molecular_function	proton transmembrane transporter activity
h	0015986	biological_process	proton motive force-driven ATP synthesis
h	0016020	cellular_component	membrane
h	0016241	biological_process	regulation of macroautophagy
h	0030177	biological_process	positive regulation of Wnt signaling pathway
h	0030665	cellular_component	clathrin-coated vesicle membrane
h	0030670	cellular_component	phagocytic vesicle membrane
h	0030672	cellular_component	synaptic vesicle membrane
h	0031625	molecular_function	ubiquitin protein ligase binding
h	0033176	cellular_component	proton-transporting V-type ATPase complex
h	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
h	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
h	0035577	cellular_component	azurophil granule membrane
h	0046611	cellular_component	lysosomal proton-transporting V-type ATPase complex
h	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
h	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
h	0048388	biological_process	endosomal lumen acidification
h	0051452	biological_process	intracellular pH reduction
h	0061795	biological_process	Golgi lumen acidification
h	0070062	cellular_component	extracellular exosome
h	0070821	cellular_component	tertiary granule membrane
h	0071230	biological_process	cellular response to amino acid stimulus
h	0097401	biological_process	synaptic vesicle lumen acidification
h	0098588	cellular_component	bounding membrane of organelle
h	0101003	cellular_component	ficolin-1-rich granule membrane
h	0160124	molecular_function	guanyl nucleotide exchange factor activator activity
h	1902600	biological_process	proton transmembrane transport
h	1904263	biological_process	positive regulation of TORC1 signaling
i	0000139	cellular_component	Golgi membrane
i	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
i	0005515	molecular_function	protein binding
i	0005765	cellular_component	lysosomal membrane
i	0005886	cellular_component	plasma membrane
i	0005925	cellular_component	focal adhesion
i	0007035	biological_process	vacuolar acidification
i	0007042	biological_process	lysosomal lumen acidification
i	0010008	cellular_component	endosome membrane
i	0015078	molecular_function	proton transmembrane transporter activity
i	0015986	biological_process	proton motive force-driven ATP synthesis
i	0016020	cellular_component	membrane
i	0016241	biological_process	regulation of macroautophagy
i	0030177	biological_process	positive regulation of Wnt signaling pathway
i	0030665	cellular_component	clathrin-coated vesicle membrane
i	0030670	cellular_component	phagocytic vesicle membrane
i	0030672	cellular_component	synaptic vesicle membrane
i	0031625	molecular_function	ubiquitin protein ligase binding
i	0033176	cellular_component	proton-transporting V-type ATPase complex
i	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
i	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
i	0035577	cellular_component	azurophil granule membrane
i	0046611	cellular_component	lysosomal proton-transporting V-type ATPase complex
i	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
i	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
i	0048388	biological_process	endosomal lumen acidification
i	0051452	biological_process	intracellular pH reduction
i	0061795	biological_process	Golgi lumen acidification
i	0070062	cellular_component	extracellular exosome
i	0070821	cellular_component	tertiary granule membrane
i	0071230	biological_process	cellular response to amino acid stimulus
i	0097401	biological_process	synaptic vesicle lumen acidification
i	0098588	cellular_component	bounding membrane of organelle
i	0101003	cellular_component	ficolin-1-rich granule membrane
i	0160124	molecular_function	guanyl nucleotide exchange factor activator activity
i	1902600	biological_process	proton transmembrane transport
i	1904263	biological_process	positive regulation of TORC1 signaling
j	0000139	cellular_component	Golgi membrane
j	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
j	0005515	molecular_function	protein binding
j	0005765	cellular_component	lysosomal membrane
j	0005886	cellular_component	plasma membrane
j	0005925	cellular_component	focal adhesion
j	0007035	biological_process	vacuolar acidification
j	0007042	biological_process	lysosomal lumen acidification
j	0010008	cellular_component	endosome membrane
j	0015078	molecular_function	proton transmembrane transporter activity
j	0015986	biological_process	proton motive force-driven ATP synthesis
j	0016020	cellular_component	membrane
j	0016241	biological_process	regulation of macroautophagy
j	0030177	biological_process	positive regulation of Wnt signaling pathway
j	0030665	cellular_component	clathrin-coated vesicle membrane
j	0030670	cellular_component	phagocytic vesicle membrane
j	0030672	cellular_component	synaptic vesicle membrane
j	0031625	molecular_function	ubiquitin protein ligase binding
j	0033176	cellular_component	proton-transporting V-type ATPase complex
j	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
j	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
j	0035577	cellular_component	azurophil granule membrane
j	0046611	cellular_component	lysosomal proton-transporting V-type ATPase complex
j	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
j	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
j	0048388	biological_process	endosomal lumen acidification
j	0051452	biological_process	intracellular pH reduction
j	0061795	biological_process	Golgi lumen acidification
j	0070062	cellular_component	extracellular exosome
j	0070821	cellular_component	tertiary granule membrane
j	0071230	biological_process	cellular response to amino acid stimulus
j	0097401	biological_process	synaptic vesicle lumen acidification
j	0098588	cellular_component	bounding membrane of organelle
j	0101003	cellular_component	ficolin-1-rich granule membrane
j	0160124	molecular_function	guanyl nucleotide exchange factor activator activity
j	1902600	biological_process	proton transmembrane transport
j	1904263	biological_process	positive regulation of TORC1 signaling
k	0000139	cellular_component	Golgi membrane
k	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
k	0005515	molecular_function	protein binding
k	0005765	cellular_component	lysosomal membrane
k	0005886	cellular_component	plasma membrane
k	0005925	cellular_component	focal adhesion
k	0007035	biological_process	vacuolar acidification
k	0007042	biological_process	lysosomal lumen acidification
k	0010008	cellular_component	endosome membrane
k	0015078	molecular_function	proton transmembrane transporter activity
k	0015986	biological_process	proton motive force-driven ATP synthesis
k	0016020	cellular_component	membrane
k	0016241	biological_process	regulation of macroautophagy
k	0030177	biological_process	positive regulation of Wnt signaling pathway
k	0030665	cellular_component	clathrin-coated vesicle membrane
k	0030670	cellular_component	phagocytic vesicle membrane
k	0030672	cellular_component	synaptic vesicle membrane
k	0031625	molecular_function	ubiquitin protein ligase binding
k	0033176	cellular_component	proton-transporting V-type ATPase complex
k	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
k	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
k	0035577	cellular_component	azurophil granule membrane
k	0046611	cellular_component	lysosomal proton-transporting V-type ATPase complex
k	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
k	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
k	0048388	biological_process	endosomal lumen acidification
k	0051452	biological_process	intracellular pH reduction
k	0061795	biological_process	Golgi lumen acidification
k	0070062	cellular_component	extracellular exosome
k	0070821	cellular_component	tertiary granule membrane
k	0071230	biological_process	cellular response to amino acid stimulus
k	0097401	biological_process	synaptic vesicle lumen acidification
k	0098588	cellular_component	bounding membrane of organelle
k	0101003	cellular_component	ficolin-1-rich granule membrane
k	0160124	molecular_function	guanyl nucleotide exchange factor activator activity
k	1902600	biological_process	proton transmembrane transport
k	1904263	biological_process	positive regulation of TORC1 signaling
l	0000139	cellular_component	Golgi membrane
l	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
l	0005515	molecular_function	protein binding
l	0005765	cellular_component	lysosomal membrane
l	0005886	cellular_component	plasma membrane
l	0005925	cellular_component	focal adhesion
l	0007035	biological_process	vacuolar acidification
l	0007042	biological_process	lysosomal lumen acidification
l	0010008	cellular_component	endosome membrane
l	0015078	molecular_function	proton transmembrane transporter activity
l	0015986	biological_process	proton motive force-driven ATP synthesis
l	0016020	cellular_component	membrane
l	0016241	biological_process	regulation of macroautophagy
l	0030177	biological_process	positive regulation of Wnt signaling pathway
l	0030665	cellular_component	clathrin-coated vesicle membrane
l	0030670	cellular_component	phagocytic vesicle membrane
l	0030672	cellular_component	synaptic vesicle membrane
l	0031625	molecular_function	ubiquitin protein ligase binding
l	0033176	cellular_component	proton-transporting V-type ATPase complex
l	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
l	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
l	0035577	cellular_component	azurophil granule membrane
l	0046611	cellular_component	lysosomal proton-transporting V-type ATPase complex
l	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
l	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
l	0048388	biological_process	endosomal lumen acidification
l	0051452	biological_process	intracellular pH reduction
l	0061795	biological_process	Golgi lumen acidification
l	0070062	cellular_component	extracellular exosome
l	0070821	cellular_component	tertiary granule membrane
l	0071230	biological_process	cellular response to amino acid stimulus
l	0097401	biological_process	synaptic vesicle lumen acidification
l	0098588	cellular_component	bounding membrane of organelle
l	0101003	cellular_component	ficolin-1-rich granule membrane
l	0160124	molecular_function	guanyl nucleotide exchange factor activator activity
l	1902600	biological_process	proton transmembrane transport
l	1904263	biological_process	positive regulation of TORC1 signaling
m	0000139	cellular_component	Golgi membrane
m	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
m	0005515	molecular_function	protein binding
m	0005765	cellular_component	lysosomal membrane
m	0005886	cellular_component	plasma membrane
m	0005925	cellular_component	focal adhesion
m	0007035	biological_process	vacuolar acidification
m	0007042	biological_process	lysosomal lumen acidification
m	0010008	cellular_component	endosome membrane
m	0015078	molecular_function	proton transmembrane transporter activity
m	0015986	biological_process	proton motive force-driven ATP synthesis
m	0016020	cellular_component	membrane
m	0016241	biological_process	regulation of macroautophagy
m	0030177	biological_process	positive regulation of Wnt signaling pathway
m	0030665	cellular_component	clathrin-coated vesicle membrane
m	0030670	cellular_component	phagocytic vesicle membrane
m	0030672	cellular_component	synaptic vesicle membrane
m	0031625	molecular_function	ubiquitin protein ligase binding
m	0033176	cellular_component	proton-transporting V-type ATPase complex
m	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
m	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
m	0035577	cellular_component	azurophil granule membrane
m	0046611	cellular_component	lysosomal proton-transporting V-type ATPase complex
m	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
m	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
m	0048388	biological_process	endosomal lumen acidification
m	0051452	biological_process	intracellular pH reduction
m	0061795	biological_process	Golgi lumen acidification
m	0070062	cellular_component	extracellular exosome
m	0070821	cellular_component	tertiary granule membrane
m	0071230	biological_process	cellular response to amino acid stimulus
m	0097401	biological_process	synaptic vesicle lumen acidification
m	0098588	cellular_component	bounding membrane of organelle
m	0101003	cellular_component	ficolin-1-rich granule membrane
m	0160124	molecular_function	guanyl nucleotide exchange factor activator activity
m	1902600	biological_process	proton transmembrane transport
m	1904263	biological_process	positive regulation of TORC1 signaling
n	0000139	cellular_component	Golgi membrane
n	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
n	0005515	molecular_function	protein binding
n	0005765	cellular_component	lysosomal membrane
n	0005886	cellular_component	plasma membrane
n	0005925	cellular_component	focal adhesion
n	0007035	biological_process	vacuolar acidification
n	0007042	biological_process	lysosomal lumen acidification
n	0010008	cellular_component	endosome membrane
n	0015078	molecular_function	proton transmembrane transporter activity
n	0015986	biological_process	proton motive force-driven ATP synthesis
n	0016020	cellular_component	membrane
n	0016241	biological_process	regulation of macroautophagy
n	0030177	biological_process	positive regulation of Wnt signaling pathway
n	0030665	cellular_component	clathrin-coated vesicle membrane
n	0030670	cellular_component	phagocytic vesicle membrane
n	0030672	cellular_component	synaptic vesicle membrane
n	0031625	molecular_function	ubiquitin protein ligase binding
n	0033176	cellular_component	proton-transporting V-type ATPase complex
n	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
n	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
n	0035577	cellular_component	azurophil granule membrane
n	0046611	cellular_component	lysosomal proton-transporting V-type ATPase complex
n	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
n	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
n	0048388	biological_process	endosomal lumen acidification
n	0051452	biological_process	intracellular pH reduction
n	0061795	biological_process	Golgi lumen acidification
n	0070062	cellular_component	extracellular exosome
n	0070821	cellular_component	tertiary granule membrane
n	0071230	biological_process	cellular response to amino acid stimulus
n	0097401	biological_process	synaptic vesicle lumen acidification
n	0098588	cellular_component	bounding membrane of organelle
n	0101003	cellular_component	ficolin-1-rich granule membrane
n	0160124	molecular_function	guanyl nucleotide exchange factor activator activity
n	1902600	biological_process	proton transmembrane transport
n	1904263	biological_process	positive regulation of TORC1 signaling
p	0016020	cellular_component	membrane
p	0038023	molecular_function	signaling receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1150
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WLW","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6WM2","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WLW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WLW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	188
Details	Topological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	415
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Site: {"description":"Essential for proton translocation","evidences":[{"source":"UniProtKB","id":"Q2TA24","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	9
Details	Site: {"description":"Essential for proton translocation","evidences":[{"source":"PubMed","id":"36074901","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P51863","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P51863","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	129
Details	Topological domain: {"description":"Vacuolar","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---