9DBP
Crystal structure of the LSD1/CoREST histone demethylase in complex with the cofactor FAD and the inhibitor GSK690
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysine-specific histone demethylase 1A | polymer | 660 | 73305.8 | 1 | UniProt (O60341) Pfam (PF04433) Pfam (PF01593) | Homo sapiens (human) | BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2,[histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A |
| 2 | B (B) | REST corepressor 1 | polymer | 131 | 14800.8 | 1 | UniProt (Q9UKL0) Pfam (PF20878) Pfam (PF00249) | Homo sapiens (human) | Protein CoREST |
| 3 | C (A) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) | |||
| 4 | D, E (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | F (A) | 4-[2-(4-methylphenyl)-5-{[(3R)-pyrrolidin-3-yl]methoxy}pyridin-3-yl]benzonitrile | non-polymer | 369.5 | 1 | Chemie (A1A5U) | |||
| 6 | G (A) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 172 - 831 (UniProt: O60341)
B: 309 - 439 (UniProt: Q9UKL0)
| PDB | External Database | Details |
|---|---|---|
| Ala 269 | Arg 269 | engineered mutation |
| Ala 469 | Lys 469 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 312 | Lys 315 | engineered mutation |
| Ala 378 | Lys 381 | engineered mutation |
| Ala 422 | Val 425 | engineered mutation |
| Ala 425 | Arg 428 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 88106.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1339.2 | |
| All* | Total formula weight | 89445.7 |
