9CUC

Human STING G230A/R293Q variant bound to THIQi

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Stimulator of interferon genes protein	polymer	210	24038.9	6	UniProt (Q86WV6)	Homo sapiens (human)	hSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,hMITA,Transmembrane protein 173
2	G, H, I, J, K... (A, B, C, D, E...)	(3S,4S)-2-(4-tert-butyl-3-chlorophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid	non-polymer		492.0	6	Chemie (A1A4R)
3	M, N, O, P, Q... (A, B, C, D, E...)	water	water		18.0	73	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 155 - 341 (UniProt: Q86WV6)

PDB	External Database	Details
Met 132	-	initiating methionine
Gly 133	-	expression tag
Ser 134	-	expression tag
Ser 135	-	expression tag
His 136	-	expression tag
His 137	-	expression tag
His 138	-	expression tag
His 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
Ser 142	-	expression tag
Ser 143	-	expression tag
Gly 144	-	expression tag
Glu 145	-	expression tag
Thr 146	-	expression tag
Val 147	-	expression tag
Arg 148	-	expression tag
Phe 149	-	expression tag
Gln 150	-	expression tag
Gly 151	-	expression tag
His 152	-	expression tag
Met 153	-	expression tag
Ser 154	-	expression tag
Ala 230	Gly 230	variant
Arg 232	His 232	conflict
Gln 293	Arg 293	variant

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	144233.4
Non-Polymers*	Number of molecules	6
	Total formula weight	2951.8
All*	Total formula weight	147185.2

*Water molecules are not included.