9CTH
Preliminary map of the Prothrombin-prothrombinase complex on nano discs
This is a non-PDB format compatible entry.
Replaces: 7TPQEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Activated Factor V (FVa) heavy chain | polymer | 709 | 81274.4 | 1 | UniProt (P12259) Pfam (PF07732) | Homo sapiens (human) | Coagulation factor Va heavy chain,Activated protein C cofactor,Proaccelerin,labile factor |
| 2 | B (E) | Activated Factor V (FVa) light chain | polymer | 651 | 75283.0 | 1 | UniProt (P12259) Pfam (PF07732) Pfam (PF00754) | Homo sapiens (human) | Coagulation factor Va light chain,Activated protein C cofactor,Proaccelerin,labile factor |
| 3 | C (B) | Activated Factor X light chain | polymer | 142 | 16187.0 | 1 | UniProt (P00742) Pfam (PF00594) Pfam (PF00008) Pfam (PF14670) | Homo sapiens (human) | FXa-LC,Factor X light chain |
| 4 | D (C) | Activated Factor X heavy chain | polymer | 235 | 26588.3 | 1 | UniProt (P00742) Pfam (PF00089) | Homo sapiens (human) | FXa-HC,Factor X heavy chain |
| 5 | E (D) | Prothrombin | polymer | 579 | 65370.1 | 1 | UniProt (P00734) Pfam (PF00089) Pfam (PF00594) Pfam (PF00051) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II |
| 6 | F, G, H, I, J... (A, E, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) |
Sequence modifications
C: 16 - 245 (UniProt: P00742)
D: 1 - 579 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Ser 419 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 525 | Ser 568 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 264702.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1327.2 | |
| All* | Total formula weight | 266030.0 |
