9CPA
Structure of a Mammalian DHX29-bound 43S Pre-initiation Complex
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (l) | eL41 | polymer | 25 | 3473.5 | 1 | UniProt (A0A087WNH4) Pfam (PF05162) | Oryctolagus cuniculus (rabbit) | 60s ribosomal protein l41 |
| 2 | B (C) | uS2 (SA) | polymer | 295 | 32928.0 | 1 | UniProt (G1TLT8) Pfam (PF00318) Pfam (PF16122) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein SA, 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40 |
| 3 | C (E) | Small ribosomal subunit protein uS5 | polymer | 226 | 24814.3 | 1 | Pfam (PF00333) Pfam (PF03719) UniProt (by SIFTS) (G1SWM1) | Oryctolagus cuniculus (rabbit) | |
| 4 | D (G) | 40S ribosomal protein S4 | polymer | 263 | 29658.9 | 1 | UniProt (G1TK17) Pfam (PF08071) Pfam (PF00900) Pfam (PF00467) Pfam (PF16121) | Oryctolagus cuniculus (rabbit) | |
| 5 | E (I) | 40S ribosomal protein S6 | polymer | 249 | 28751.9 | 1 | UniProt (G1TM55) Pfam (PF01092) | Oryctolagus cuniculus (rabbit) | |
| 6 | F (J) | 40S ribosomal protein S7 | polymer | 194 | 22168.9 | 1 | UniProt (G1SVB0) Pfam (PF01251) | Oryctolagus cuniculus (rabbit) | |
| 7 | G (K) | Small ribosomal subunit protein eS8 | polymer | 208 | 24163.2 | 1 | UniProt (G1TJW1) Pfam (PF01201) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S8 |
| 8 | H (L) | Ribosomal protein S9 (Predicted) | polymer | 194 | 22641.6 | 1 | UniProt (B7NZS8) Pfam (PF00163) Pfam (PF01479) | Oryctolagus cuniculus (rabbit) | |
| 9 | I (N) | Ribosomal protein S11 | polymer | 158 | 18468.8 | 1 | UniProt (G1TRM4) Pfam (PF16205) Pfam (PF00366) | Oryctolagus cuniculus (rabbit) | |
| 10 | J (P) | Ribosomal protein S13 | polymer | 151 | 17259.4 | 1 | UniProt (G1SP51) Pfam (PF08069) Pfam (PF00312) | Oryctolagus cuniculus (rabbit) | |
| 11 | K (X) | 40S ribosomal protein S21 | polymer | 83 | 9043.3 | 1 | UniProt (G1TM82) Pfam (PF01249) | Oryctolagus cuniculus (rabbit) | |
| 12 | L (Y) | Ribosomal protein S15a | polymer | 130 | 14865.6 | 1 | UniProt (G1TG89) Pfam (PF00410) | Oryctolagus cuniculus (rabbit) | |
| 13 | M (Z) | uS12 | polymer | 143 | 15844.7 | 1 | UniProt (G1SZ47) Pfam (PF00164) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S23 |
| 14 | N (a) | 40S ribosomal protein S24 | polymer | 133 | 15434.3 | 1 | UniProt (G1TS40) Pfam (PF01282) UniProt (by SIFTS) (A0A5F9D2E6) | Oryctolagus cuniculus (rabbit) | |
| 15 | O (c) | 40S ribosomal protein S27 | polymer | 84 | 9480.2 | 1 | UniProt (G1TZ76) Pfam (PF01667) | Oryctolagus cuniculus (rabbit) | |
| 16 | P (i) | 40S ribosomal protein S30 | polymer | 133 | 14498.9 | 1 | UniProt (G1T8A2) Pfam (PF00240) Pfam (PF04758) | Oryctolagus cuniculus (rabbit) | |
| 17 | Q (2) | 18S ribosomal RNA | polymer | 1863 | 600756.5 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 18 | R (F) | Ribosomal protein S3 | polymer | 243 | 26715.3 | 1 | UniProt (G1TNM3) Pfam (PF07650) Pfam (PF00189) | Oryctolagus cuniculus (rabbit) | |
| 19 | S (H) | Small ribosomal subunit protein uS7 | polymer | 219 | 24471.2 | 1 | UniProt (U3KMN4) Pfam (PF00177) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S5 |
| 20 | T (M) | S10_plectin domain-containing protein | polymer | 165 | 18933.8 | 1 | UniProt (G1TPV3) Pfam (PF03501) | Oryctolagus cuniculus (rabbit) | |
| 21 | U (O) | 40S ribosomal protein S12 | polymer | 132 | 14539.0 | 1 | UniProt (G1SFR8) Pfam (PF01248) | Oryctolagus cuniculus (rabbit) | |
| 22 | V (S) | uS9 | polymer | 146 | 16477.4 | 1 | UniProt (G1SGX4) Pfam (PF00380) | Oryctolagus cuniculus (rabbit) | |
| 23 | W (T) | eS17 | polymer | 135 | 15552.1 | 1 | UniProt (G1TU13) Pfam (PF00833) | Oryctolagus cuniculus (rabbit) | |
| 24 | X (V) | eS19 | polymer | 145 | 16235.8 | 1 | UniProt (G1TN62) Pfam (PF01090) | Oryctolagus cuniculus (rabbit) | |
| 25 | Y (W) | uS10 | polymer | 119 | 13398.8 | 1 | UniProt (G1SIZ2) Pfam (PF00338) | Oryctolagus cuniculus (rabbit) | |
| 26 | Z (d) | Ribosomal protein S28 | polymer | 69 | 7855.1 | 1 | UniProt (G1TIB4) Pfam (PF01200) | Oryctolagus cuniculus (rabbit) | |
| 27 | AA (e) | eS29 | polymer | 56 | 6690.8 | 1 | UniProt (G1U7M4) Pfam (PF00253) | Oryctolagus cuniculus (rabbit) | |
| 28 | BA (f) | Ribosomal protein S27a | polymer | 156 | 18004.0 | 1 | UniProt (G1SK22) Pfam (PF00240) Pfam (PF01599) | Oryctolagus cuniculus (rabbit) | |
| 29 | CA (g) | RACK1 | polymer | 317 | 35115.7 | 1 | UniProt (G1SJB4) Pfam (PF00400) | Oryctolagus cuniculus (rabbit) | |
| 30 | DA (n) | eS25 | polymer | 124 | 13645.0 | 1 | UniProt (G1TDB3) Pfam (PF03297) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S25 |
| 31 | EA (U) | uS13 | polymer | 152 | 17759.8 | 1 | UniProt (G1TPG3) Pfam (PF00416) | Oryctolagus cuniculus (rabbit) | |
| 32 | FA (R) | uS19 | polymer | 145 | 17049.2 | 1 | UniProt (G1U0Q2) Pfam (PF00203) | Oryctolagus cuniculus (rabbit) | |
| 33 | GA (D) | Eukaryotic translation initiation factor 3 subunit D | polymer | 557 | 64959.7 | 1 | UniProt (G1SQV5) Pfam (PF05091) | Oryctolagus cuniculus (rabbit) | eIF3d,Eukaryotic translation initiation factor 3 subunit 7,eIF-3-zeta |
| 34 | HA (y) | Eukaryotic translation initiation factor 3 subunit A | polymer | 1350 | 163226.9 | 1 | UniProt (A0A5F9C991) Pfam (PF22591) Pfam (PF01399) | Oryctolagus cuniculus (rabbit) | eIF3a,Eukaryotic translation initiation factor 3 subunit 10,eIF-3-theta |
| 35 | IA (q) | Eukaryotic translation initiation factor 3 subunit F | polymer | 364 | 37846.7 | 1 | UniProt (G1SLC2) Pfam (PF01398) Pfam (PF13012) | Oryctolagus cuniculus (rabbit) | eIF3f,Eukaryotic translation initiation factor 3 subunit 5,eIF-3-epsilon,eIF3 p47 |
| 36 | JA (r) | Eukaryotic translation initiation factor 3 subunit H | polymer | 366 | 42035.9 | 1 | UniProt (A0A5F9CZR4) Pfam (PF01398) Pfam (PF19445) | Oryctolagus cuniculus (rabbit) | eIF3h,Eukaryotic translation initiation factor 3 subunit 3,eIF-3 gamma,eIF3 p40 subunit |
| 37 | KA (s) | Eukaryotic translation initiation factor 3 subunit K | polymer | 218 | 25129.7 | 1 | UniProt (G1T3L2) Pfam (PF10075) | Oryctolagus cuniculus (rabbit) | eIF3k,Eukaryotic translation initiation factor 3 subunit 12,eIF-3 p25 |
| 38 | LA (t) | Eukaryotic translation initiation factor 3 subunit L | polymer | 564 | 66776.7 | 1 | UniProt (G1SED9) Pfam (PF10255) | Oryctolagus cuniculus (rabbit) | eIF3l,Eukaryotic translation initiation factor 3 subunit 6-interacting protein,Eukaryotic translation initiation factor 3 subunit E-interacting protein |
| 39 | MA (u) | Eukaryotic translation initiation factor 3 subunit M | polymer | 374 | 42555.8 | 1 | UniProt (G1SLW8) Pfam (PF01399) Pfam (PF18005) | Oryctolagus cuniculus (rabbit) | eIF3m |
| 40 | NA (1) | initiator methionylated tRNA | polymer | 75 | 24376.6 | 1 | Oryctolagus cuniculus (rabbit) | ||
| 41 | OA (A) | Eukaryotic translation initiation factor 2 subunit 1 | polymer | 284 | 32792.9 | 1 | UniProt (G1T2G4) Pfam (PF00575) Pfam (PF07541) | Oryctolagus cuniculus (rabbit) | Eukaryotic translation initiation factor 2 subunit alpha |
| 42 | PA (B) | protein-synthesizing GTPase | polymer | 422 | 45862.4 | 1 | UniProt (A0A6P3CWF8) | Oryctolagus cuniculus (rabbit) | |
| 43 | QA (p) | eukaryotic translation initiation factor 3 subunit b | polymer | 814 | 92231.9 | 1 | Pfam (PF00076) Pfam (PF08662) UniProt (by SIFTS) (P55884) | Oryctolagus cuniculus (rabbit) | |
| 44 | RA (z) | eukaryotic translation initiation factor 3 subunit i | polymer | 342 | 38229.8 | 1 | Pfam (PF00400) UniProt (by SIFTS) (P40217) | Oryctolagus cuniculus (rabbit) | |
| 45 | SA (x) | Small ribosomal subunit protein eS1 | polymer | 264 | 29929.0 | 1 | UniProt (G1TN72) Pfam (PF01015) | Oryctolagus cuniculus (rabbit) | |
| 46 | TA (0) | Small ribosomal subunit protein uS11 | polymer | 151 | 16302.8 | 1 | UniProt (G1T1F0) Pfam (PF00411) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S14 |
| 47 | UA (Q) | Eukaryotic translation initiation factor 3 subunit E | polymer | 462 | 54199.9 | 1 | UniProt (G1SUC8) Pfam (PF09440) Pfam (PF01399) Pfam (PF21357) | Oryctolagus cuniculus (rabbit) | eIF3e,Eukaryotic translation initiation factor 3 subunit 6,eIF-3 p48 |
| 48 | VA (j) | Eukaryotic translation initiation factor 3 subunit g | polymer | 320 | 35662.0 | 1 | Pfam (PF12353) Pfam (PF00076) UniProt (by SIFTS) (O75821) | Oryctolagus cuniculus (rabbit) | |
| 49 | WA (b) | 40S ribosomal protein S26 | polymer | 115 | 12961.5 | 1 | UniProt (G1TFE8) Pfam (PF01283) | Oryctolagus cuniculus (rabbit) | |
| 50 | XA (k) | Eukaryotic translation initiation factor 3 subunit C | polymer | 913 | 105676.2 | 1 | UniProt (G1U971) Pfam (PF05470) Pfam (PF01399) Pfam (PF26569) | Oryctolagus cuniculus (rabbit) | eIF3c,Eukaryotic translation initiation factor 3 subunit 8,eIF3 p110 |
| 51 | YA (h) | ATP-dependent RNA helicase DHX29 | polymer | 1369 | 155454.1 | 1 | UniProt (Q7Z478) Pfam (PF24899) Pfam (PF24385) Pfam (PF00270) Pfam (PF00271) Pfam (PF04408) Pfam (PF21010) Pfam (PF07717) Pfam (PF26026) | Homo sapiens (human) | DEAH box protein 29,Nucleic acid helicase DDXx |
Sequence modifications
r: -13 - 352 (UniProt: A0A5F9CZR4)
t: 1 - 564 (UniProt: G1SED9)
| PDB | External Database | Details |
|---|---|---|
| Gly 29 | Lys 43 | conflict |
| Gly 30 | Pro 44 | conflict |
| Ser 31 | Phe 45 | conflict |
| Gly 32 | Leu 46 | conflict |
| Asp 33 | Val 47 | conflict |
| Ser 34 | Ala 48 | conflict |
| Ala 35 | Tyr 49 | conflict |
| Gln 38 | Pro 52 | conflict |
| Val 39 | Cys 53 | conflict |
| Gln 40 | Phe 54 | conflict |
| Ile 41 | Ser 55 | conflict |
| Asp 42 | Arg 56 | conflict |
| Gly 43 | Thr 57 | conflict |
| Leu 44 | Arg 58 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 13 | Val 56 | conflict |
| Lys 53 | Arg 96 | conflict |
| Ala 117 | Thr 160 | conflict |
| Glu 151 | Ala 194 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 51 |
| Total formula weight | 2252905.2 | |
| All* | Total formula weight | 2252905.2 |
