9CP4
Cryo-EM structure of human GAT3 in complex with SNAP-5114, inward-open conformation
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sodium- and chloride-dependent GABA transporter 3 | polymer | 641 | 71518.5 | 1 | UniProt (P48066) Pfam (PF00209) | Homo sapiens (human) | GAT-3,Solute carrier family 6 member 11 |
| 2 | B (H) | 9D5 heavy chain | polymer | 242 | 26242.3 | 1 | Mus musculus (mouse) | ||
| 3 | C (L) | 9D5 light chain | polymer | 214 | 23306.6 | 1 | Mus musculus (mouse) | ||
| 4 | D (A) | (3S)-1-{2-[tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid | non-polymer | 505.6 | 1 | Chemie (A1AZJ) | |||
| 5 | E (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) |
Sequence modifications
A: 1 - 632 (UniProt: P48066)
| PDB | External Database | Details |
|---|---|---|
| His 327 | Asn 327 | engineered mutation |
| Ser 497 | Tyr 497 | engineered mutation |
| Glu 498 | Asp 498 | engineered mutation |
| Asp 499 | Asn 499 | engineered mutation |
| Arg 501 | Glu 501 | engineered mutation |
| Phe 506 | Tyr 506 | engineered mutation |
| Pro 507 | Arg 507 | engineered mutation |
| Ala 633 | - | expression tag |
| Ala 634 | - | expression tag |
| Ala 635 | - | expression tag |
| Leu 636 | - | expression tag |
| Glu 637 | - | expression tag |
| Val 638 | - | expression tag |
| Leu 639 | - | expression tag |
| Phe 640 | - | expression tag |
| Gln 641 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 121067.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 541.1 | |
| All* | Total formula weight | 121608.4 |
