9CIB
CryoEM Structure of HCA2 DREADD Gi1 in complex with FCH-2296413 (Local Refinement)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Hydroxycarboxylic acid receptor 2 | polymer | 294 | 34247.7 | 1 | UniProt (Q9EP66) Pfam (PF00001) | Mus musculus (house mouse) | G-protein coupled receptor 109,G-protein coupled receptor 109A,G-protein coupled receptor HM74,Niacin receptor 1,Nicotinic acid receptor,Protein PUMA-G |
| 2 | B (R) | (3M,4aR,5aR)-3-(1H-tetrazol-5-yl)-4,4a,5,5a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole | non-polymer | 188.2 | 1 | Chemie (XI9) |
Sequence modifications
R: 4 - 297 (UniProt: Q9EP66)
| PDB | External Database | Details |
|---|---|---|
| Lys 108 | Arg 108 | engineered mutation |
| Ala 121 | Asp 121 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34247.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 188.2 | |
| All* | Total formula weight | 34435.9 |
