9CHY
Crystal structure of the human MESH1 (D66K)-PAPS complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 | polymer | 180 | 20514.3 | 2 | UniProt (Q8N4P3) Pfam (PF13328) | Homo sapiens (human) | HD domain-containing protein 3,Metazoan SpoT homolog 1,MESH1,Penta-phosphate guanosine-3'-pyrophosphohydrolase,(ppGpp)ase |
| 2 | C, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, G (A, B) | 3'-PHOSPHATE-ADENOSINE-5'-PHOSPHATE SULFATE | non-polymer | 507.3 | 2 | Chemie (PPS) | |||
| 4 | E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | H (B) | ACETIC ACID | non-polymer | 60.1 | 1 | Chemie (ACY) | |||
| 6 | I, J (A, B) | water | water | 18.0 | 309 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 179 (UniProt: Q8N4P3)
| PDB | External Database | Details |
|---|---|---|
| His 0 | - | expression tag |
| Lys 66 | Asp 66 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 41028.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1267.5 | |
| All* | Total formula weight | 42296.0 |
