9CGV

SARS-CoV-2 nsp12 NiRAN domain bound to a covalent inhibitor SW090466-1

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	RNA-directed RNA polymerase nsp12	polymer	948	108767.1	1	UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680)	Severe acute respiratory syndrome coronavirus 2
2	B, D (B, D)	Non-structural protein 8	polymer	198	21903.0	2	UniProt (P0DTD1) Pfam (PF08717)	Severe acute respiratory syndrome coronavirus 2	nsp8
3	C (C)	Non-structural protein 7	polymer	83	9248.8	1	UniProt (P0DTD1) Pfam (PF08716)	Severe acute respiratory syndrome coronavirus 2	nsp7
4	E (P)	RNA primer	polymer	35	11157.6	1		synthetic construct
5	F (T)	RNA template	polymer	55	17641.5	1		synthetic construct
6	G, H (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
7	I (A)	methyl (8S)-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate	non-polymer		207.2	1	Chemie (A1AWQ)
8	J (A)	MANGANESE (II) ION	non-polymer		54.9	1	Chemie (MN)
9	K, L, M, N, O... (A, B, C, D, P...)	water	water		18.0	258	Chemie (HOH)

Sequence modifications

A: 0 - 932 (UniProt: P0DTD1)

PDB	External Database	Details
Met -15	-	expression tag
Gly -14	-	expression tag
Ser -13	-	expression tag
Ser -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
Glu -5	-	expression tag
Asn -4	-	expression tag
Leu -3	-	expression tag
Tyr -2	-	expression tag
Phe -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	190621.1
Non-Polymers*	Number of molecules	4
	Total formula weight	392.9
All*	Total formula weight	191014.1

*Water molecules are not included.