9CE3
Structure of the TSC:WIPI3 lysosomal recruitment complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Isoform 4 of Tuberin | polymer | 1792 | 199339.0 | 2 | UniProt (P49815) Pfam (PF11864) Pfam (PF03542) Pfam (PF02145) | Homo sapiens (human) | Tuberous sclerosis 2 protein |
| 2 | C, D (C, D) | Hamartin | polymer | 1191 | 133001.6 | 2 | UniProt (Q92574) Pfam (PF04388) | Homo sapiens (human) | Tuberous sclerosis 1 protein |
| 3 | E (E) | TBC1 domain family member 7 | polymer | 301 | 35016.5 | 1 | UniProt (Q9P0N9) Pfam (PF00566) | Homo sapiens (human) | Cell migration-inducing protein 23 |
| 4 | F (F) | WD repeat domain phosphoinositide-interacting protein 3 | polymer | 316 | 35222.4 | 1 | UniProt (Q5MNZ6) Pfam (PF21032) | Homo sapiens (human) | WIPI-3,WD repeat-containing protein 45-like,WDR45-like protein,WD repeat-containing protein 45B,WIPI49-like protein |
| 5 | G, H (G, H) | Unknown fragment | polymer | 12 | 1039.3 | 2 | Homo sapiens (human) |
Sequence modifications
A, B: 2 - 1807 (UniProt: P49815)
C, D: 1 - 1164 (UniProt: Q92574)
E: 1 - 293 (UniProt: Q9P0N9)
F: 12 - 320 (UniProt: Q5MNZ6)
| PDB | External Database | Details |
|---|---|---|
| Met -7 | - | initiating methionine |
| Asp -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Lys -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Lys 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 1165 | - | expression tag |
| Thr 1166 | - | expression tag |
| Lys 1167 | - | expression tag |
| Leu 1168 | - | expression tag |
| Gly 1169 | - | expression tag |
| Pro 1170 | - | expression tag |
| Glu 1171 | - | expression tag |
| Gln 1172 | - | expression tag |
| Lys 1173 | - | expression tag |
| Leu 1174 | - | expression tag |
| Ile 1175 | - | expression tag |
| Ser 1176 | - | expression tag |
| Glu 1177 | - | expression tag |
| Glu 1178 | - | expression tag |
| Asp 1179 | - | expression tag |
| Leu 1180 | - | expression tag |
| Asn 1181 | - | expression tag |
| Ser 1182 | - | expression tag |
| Ala 1183 | - | expression tag |
| Val 1184 | - | expression tag |
| Asp 1185 | - | expression tag |
| His 1186 | - | expression tag |
| His 1187 | - | expression tag |
| His 1188 | - | expression tag |
| His 1189 | - | expression tag |
| His 1190 | - | expression tag |
| His 1191 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 294 | - | expression tag |
| Tyr 295 | - | expression tag |
| Lys 296 | - | expression tag |
| Asp 297 | - | expression tag |
| Asp 298 | - | expression tag |
| Asp 299 | - | expression tag |
| Asp 300 | - | expression tag |
| Lys 301 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 5 | - | initiating methionine |
| His 6 | - | expression tag |
| His 7 | - | expression tag |
| His 8 | - | expression tag |
| His 9 | - | expression tag |
| His 10 | - | expression tag |
| His 11 | - | expression tag |
| - | Pro 75 | deletion |
| - | Lys 76 | deletion |
| - | Tyr 77 | deletion |
| - | Pro 78 | deletion |
| - | Pro 79 | deletion |
| - | Asn 80 | deletion |
| - | Arg 264 | deletion |
| - | Asn 265 | deletion |
| - | Lys 266 | deletion |
| - | Gln 267 | deletion |
| - | Ser 268 | deletion |
| - | Ser 269 | deletion |
| - | Leu 270 | deletion |
| - | Ala 271 | deletion |
| - | Ser 272 | deletion |
| - | Ala 273 | deletion |
| - | Ser 274 | deletion |
| - | Phe 275 | deletion |
| - | Leu 276 | deletion |
| - | Pro 277 | deletion |
| - | Lys 278 | deletion |
| - | Tyr 279 | deletion |
| - | Phe 280 | deletion |
| - | Ser 281 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 736998.6 | |
| All* | Total formula weight | 736998.6 |
