9CD6
Cryo-EM structure of respiratory supercomplex I in open state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 464 | 50637.8 | 1 | UniProt (A0A4X1SZP7) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) | Sus scrofa (pig) | |
| 2 | B (C) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | polymer | 469 | 53282.2 | 1 | UniProt (A0A480XQH6) Pfam (PF00346) | Sus scrofa (pig) | |
| 3 | C (D) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | polymer | 264 | 30241.4 | 1 | UniProt (A0A286ZNN4) Pfam (PF00329) | Sus scrofa (pig) | Complex I-30kD,NADH-ubiquinone oxidoreductase 30 kDa subunit |
| 4 | D (E) | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 249 | 27439.5 | 1 | UniProt (A0A4X1VRV3) Pfam (PF01257) | Sus scrofa (pig) | |
| 5 | E (F) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 123 | 13349.0 | 1 | UniProt (A0A4X1THU2) Pfam (PF10276) | Sus scrofa (pig) | |
| 6 | F (H) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 212 | 23893.3 | 1 | UniProt (A0A286ZUN9) Pfam (PF12838) | Sus scrofa (pig) | Complex I-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit |
| 7 | G (I) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 196 | 21795.3 | 1 | UniProt (A0A4X1VTL7) Pfam (PF01058) | Sus scrofa (pig) | Complex I-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit |
| 8 | H (J) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 175 | 19718.5 | 1 | UniProt (G8IFA6) Pfam (PF04800) | Sus scrofa (pig) | Complex I-18 kDa,NADH-ubiquinone oxidoreductase 18 kDa subunit |
| 9 | I (K) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 145 | 17162.4 | 1 | UniProt (F1SQP4) Pfam (PF05071) | Sus scrofa (pig) | |
| 10 | J (L) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | polymer | 372 | 42066.7 | 1 | UniProt (F1SL07) Pfam (PF01370) | Sus scrofa (pig) | Complex I-39kD,NADH-ubiquinone oxidoreductase 39 kDa subunit |
| 11 | K (N) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 | polymer | 116 | 13321.6 | 1 | UniProt (A0A8D0UWW0) Pfam (PF04716) | Sus scrofa (pig) | |
| 12 | L, U (O, X) | Acyl carrier protein | polymer | 156 | 17308.2 | 2 | UniProt (A0A8D1WW27) Pfam (PF00550) | Sus scrofa (pig) | |
| 13 | M (P) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 99 | 11099.8 | 1 | UniProt (A0A8D1FN21) Pfam (PF05047) | Sus scrofa (pig) | |
| 14 | N (Q) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 154 | 17890.0 | 1 | UniProt (A0A8D0Z0K9) Pfam (PF05347) | Sus scrofa (pig) | Complex I-B14,NADH-ubiquinone oxidoreductase B14 subunit |
| 15 | O (R) | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | polymer | 110 | 12172.8 | 1 | UniProt (A0A480TFA5) Pfam (PF15880) | Sus scrofa (pig) | Complex I-9kD,NADH-ubiquinone oxidoreductase 9 kDa subunit |
| 16 | P (S) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | polymer | 70 | 8034.4 | 1 | UniProt (A0A8D0TJQ4) Pfam (PF15879) | Sus scrofa (pig) | |
| 17 | Q (T) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 169 | 18319.0 | 1 | UniProt (A0A4X1VPG4) Pfam (PF14987) | Sus scrofa (pig) | Complex I-B9,NADH-ubiquinone oxidoreductase B9 subunit |
| 18 | R (U) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 357 | 40476.1 | 1 | UniProt (F1SIS9) Pfam (PF01712) | Sus scrofa (pig) | |
| 19 | S (V) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | polymer | 141 | 14686.9 | 1 | UniProt (I3LGM4) Pfam (PF02466) | Sus scrofa (pig) | |
| 20 | T (W) | NADH:ubiquinone oxidoreductase subunit A13 | polymer | 144 | 16911.6 | 1 | UniProt (A0A8D0K655) Pfam (PF06212) | Sus scrofa (pig) | |
| 21 | V (Y) | NADH:ubiquinone oxidoreductase subunit B2 | polymer | 105 | 11939.4 | 1 | UniProt (A0A8D1G9F4) Pfam (PF14813) | Sus scrofa (pig) | |
| 22 | W (Z) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | polymer | 114 | 12857.6 | 1 | UniProt (A0A8D0INK7) Pfam (PF08122) | Sus scrofa (pig) | Complex I-B12,NADH-ubiquinone oxidoreductase B12 subunit |
| 23 | X (a) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | polymer | 189 | 21587.0 | 1 | UniProt (F1SGC6) Pfam (PF09781) | Sus scrofa (pig) | |
| 24 | Y (c) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 186 | 21702.5 | 1 | UniProt (F1RWL7) Pfam (PF05821) | Sus scrofa (pig) | Complex I-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit |
| 25 | Z (d) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | polymer | 176 | 20944.8 | 1 | UniProt (A0A8D0R7A9) Pfam (PF10249) | Sus scrofa (pig) | |
| 26 | AA (e) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 154 | 17384.7 | 1 | UniProt (A0A8D1EYI7) Pfam (PF10183) | Sus scrofa (pig) | |
| 27 | BA (f) | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | polymer | 76 | 8664.1 | 1 | UniProt (A0A8D1EYQ2) | Sus scrofa (pig) | |
| 28 | CA (g) | NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 122 | 14327.7 | 1 | UniProt (A0A480JRW3) Pfam (PF06374) | Sus scrofa (pig) | |
| 29 | DA (h) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 106 | 12506.6 | 1 | UniProt (A0A4X1VX77) Pfam (PF10200) | Sus scrofa (pig) | |
| 30 | EA (i) | NADH-ubiquinone oxidoreductase chain 2 | polymer | 347 | 39077.5 | 1 | UniProt (O79875) Pfam (PF00361) Pfam (PF06444) | Sus scrofa (pig) | NADH dehydrogenase subunit 2 |
| 31 | FA (j) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 115 | 12998.4 | 1 | UniProt (O79880) Pfam (PF00507) | Sus scrofa (pig) | |
| 32 | GA (k) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 98 | 10827.3 | 1 | UniProt (P56632) Pfam (PF00420) | Sus scrofa (pig) | NADH dehydrogenase subunit 4L |
| 33 | HA (l) | NADH-ubiquinone oxidoreductase chain 5 | polymer | 606 | 68695.5 | 1 | UniProt (Q9TDR1) Pfam (PF00662) Pfam (PF00361) Pfam (PF06455) | Sus scrofa (pig) | NADH dehydrogenase subunit 5 |
| 34 | IA (m) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 175 | 19021.3 | 1 | UniProt (O79882) Pfam (PF00499) | Sus scrofa (pig) | |
| 35 | JA (n) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 58 | 7044.3 | 1 | UniProt (A0A4X1SNY5) Pfam (PF08040) | Sus scrofa (pig) | Complex I-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit |
| 36 | KA (o) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | polymer | 129 | 15117.4 | 1 | UniProt (A0A4X1T6M0) Pfam (PF07225) | Sus scrofa (pig) | |
| 37 | LA (p) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 221 | 26347.2 | 1 | UniProt (K7GSE5) Pfam (PF05347) | Sus scrofa (pig) | Complex I-B22,NADH-ubiquinone oxidoreductase B22 subunit |
| 38 | MA (q) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 51859.4 | 1 | UniProt (O79881) Pfam (PF01059) Pfam (PF00361) | Sus scrofa (pig) | NADH dehydrogenase subunit 4 |
| 39 | NA (r) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 35667.5 | 1 | UniProt (O79874) Pfam (PF00146) | Sus scrofa (pig) | NADH dehydrogenase subunit 1 |
| 40 | OA (s) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 249 | 27760.8 | 1 | UniProt (F1SLR1) Pfam (PF06747) | Sus scrofa (pig) | Complex I-19kD,NADH-ubiquinone oxidoreductase 19 kDa subunit |
| 41 | PA (t) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 137 | 16487.9 | 1 | UniProt (F1SCH1) Pfam (PF05676) | Sus scrofa (pig) | |
| 42 | QA (G) | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 727 | 79627.4 | 1 | UniProt (A0A287ARY3) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) Pfam (PF09326) Pfam (PF13510) Pfam (PF10588) | Sus scrofa (pig) | |
| 43 | RA (M) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | polymer | 113 | 12648.6 | 1 | UniProt (A0A8W4F7N8) Pfam (PF07347) | Sus scrofa (pig) | |
| 44 | SA (b) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | polymer | 128 | 15603.2 | 1 | UniProt (A0A4X1UIV8) Pfam (PF09782) | Sus scrofa (pig) | Complex I-B17,NADH-ubiquinone oxidoreductase B17 subunit |
| 45 | TA (B) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 46 | BB, CB, UA, WA, XA... (G, B, H, I) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 47 | DB, VA (G, E) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 48 | ZA (L) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 49 | AB (Q) | S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate | non-polymer | 568.7 | 1 | Chemie (ZMP) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 45 |
| Total formula weight | 1067812.6 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 4231.9 | |
| All* | Total formula weight | 1072044.5 |
