9CD6

Cryo-EM structure of respiratory supercomplex I in open state

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000166	molecular_function	nucleotide binding
B	0005743	cellular_component	mitochondrial inner membrane
B	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0022904	biological_process	respiratory electron transport chain
B	0042775	biological_process	mitochondrial ATP synthesis coupled electron transport
B	0045271	cellular_component	respiratory chain complex I
B	0046872	molecular_function	metal ion binding
B	0051287	molecular_function	NAD binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	1902600	biological_process	proton transmembrane transport
C	0005743	cellular_component	mitochondrial inner membrane
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0045271	cellular_component	respiratory chain complex I
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051539	molecular_function	4 iron, 4 sulfur cluster binding
C	1902600	biological_process	proton transmembrane transport
D	0003954	molecular_function	NADH dehydrogenase activity
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
D	0016020	cellular_component	membrane
D	0031966	cellular_component	mitochondrial membrane
D	0032981	biological_process	mitochondrial respiratory chain complex I assembly
D	0045271	cellular_component	respiratory chain complex I
D	0072593	biological_process	reactive oxygen species metabolic process
D	1902600	biological_process	proton transmembrane transport
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
E	0007399	biological_process	nervous system development
E	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
E	0045271	cellular_component	respiratory chain complex I
E	0046872	molecular_function	metal ion binding
E	0048738	biological_process	cardiac muscle tissue development
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
E	1902600	biological_process	proton transmembrane transport
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0022904	biological_process	respiratory electron transport chain
F	0045271	cellular_component	respiratory chain complex I
F	0046872	molecular_function	metal ion binding
G	0005743	cellular_component	mitochondrial inner membrane
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0016491	molecular_function	oxidoreductase activity
G	0022904	biological_process	respiratory electron transport chain
G	0045271	cellular_component	respiratory chain complex I
G	0046872	molecular_function	metal ion binding
G	0051536	molecular_function	iron-sulfur cluster binding
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
G	0051539	molecular_function	4 iron, 4 sulfur cluster binding
G	1902600	biological_process	proton transmembrane transport
J	0005743	cellular_component	mitochondrial inner membrane
J	0016020	cellular_component	membrane
J	0022904	biological_process	respiratory electron transport chain
K	0005743	cellular_component	mitochondrial inner membrane
K	0022904	biological_process	respiratory electron transport chain
K	0045271	cellular_component	respiratory chain complex I
M	0005743	cellular_component	mitochondrial inner membrane
M	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
M	0022904	biological_process	respiratory electron transport chain
M	0045271	cellular_component	respiratory chain complex I
N	0005743	cellular_component	mitochondrial inner membrane
N	0022904	biological_process	respiratory electron transport chain
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0022904	biological_process	respiratory electron transport chain
P	0045271	cellular_component	respiratory chain complex I
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0022904	biological_process	respiratory electron transport chain
Q	0031966	cellular_component	mitochondrial membrane
Q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
Q	0045271	cellular_component	respiratory chain complex I
T	0005743	cellular_component	mitochondrial inner membrane
T	0022904	biological_process	respiratory electron transport chain
T	0045271	cellular_component	respiratory chain complex I
U	0000166	molecular_function	nucleotide binding
U	0005525	molecular_function	GTP binding
U	0005759	cellular_component	mitochondrial matrix
U	0022904	biological_process	respiratory electron transport chain
U	0046872	molecular_function	metal ion binding
V	0005743	cellular_component	mitochondrial inner membrane
V	0045271	cellular_component	respiratory chain complex I
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0016020	cellular_component	membrane
W	0022904	biological_process	respiratory electron transport chain
W	0045271	cellular_component	respiratory chain complex I
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0022904	biological_process	respiratory electron transport chain
Z	0005743	cellular_component	mitochondrial inner membrane
Z	0022904	biological_process	respiratory electron transport chain
a	0005739	cellular_component	mitochondrion
a	0005743	cellular_component	mitochondrial inner membrane
a	0022904	biological_process	respiratory electron transport chain
a	0045271	cellular_component	respiratory chain complex I
b	0005743	cellular_component	mitochondrial inner membrane
b	0022904	biological_process	respiratory electron transport chain
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
c	0022904	biological_process	respiratory electron transport chain
c	0045271	cellular_component	respiratory chain complex I
g	0005737	cellular_component	cytoplasm
g	0005743	cellular_component	mitochondrial inner membrane
g	0022904	biological_process	respiratory electron transport chain
g	0032981	biological_process	mitochondrial respiratory chain complex I assembly
g	0045271	cellular_component	respiratory chain complex I
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0005758	cellular_component	mitochondrial intermembrane space
h	0022904	biological_process	respiratory electron transport chain
h	0032981	biological_process	mitochondrial respiratory chain complex I assembly
h	0045271	cellular_component	respiratory chain complex I
i	0005743	cellular_component	mitochondrial inner membrane
i	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
i	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
i	0022904	biological_process	respiratory electron transport chain
i	0032981	biological_process	mitochondrial respiratory chain complex I assembly
i	0045271	cellular_component	respiratory chain complex I
i	1902600	biological_process	proton transmembrane transport
j	0005743	cellular_component	mitochondrial inner membrane
j	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
j	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
j	0022904	biological_process	respiratory electron transport chain
j	0045271	cellular_component	respiratory chain complex I
j	1902600	biological_process	proton transmembrane transport
k	0005743	cellular_component	mitochondrial inner membrane
k	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
k	0022904	biological_process	respiratory electron transport chain
k	0045271	cellular_component	respiratory chain complex I
k	1902600	biological_process	proton transmembrane transport
l	0005743	cellular_component	mitochondrial inner membrane
l	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
l	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
l	0015990	biological_process	electron transport coupled proton transport
l	0022904	biological_process	respiratory electron transport chain
l	0032981	biological_process	mitochondrial respiratory chain complex I assembly
l	0045271	cellular_component	respiratory chain complex I
m	0005739	cellular_component	mitochondrion
m	0005743	cellular_component	mitochondrial inner membrane
m	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
m	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
m	0022904	biological_process	respiratory electron transport chain
m	0032981	biological_process	mitochondrial respiratory chain complex I assembly
m	0045271	cellular_component	respiratory chain complex I
m	1902600	biological_process	proton transmembrane transport
o	0005743	cellular_component	mitochondrial inner membrane
o	0022904	biological_process	respiratory electron transport chain
o	0045271	cellular_component	respiratory chain complex I
p	0005739	cellular_component	mitochondrion
p	0005743	cellular_component	mitochondrial inner membrane
p	0022904	biological_process	respiratory electron transport chain
p	0045271	cellular_component	respiratory chain complex I
q	0003954	molecular_function	NADH dehydrogenase activity
q	0005743	cellular_component	mitochondrial inner membrane
q	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
q	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
q	0009060	biological_process	aerobic respiration
q	0015990	biological_process	electron transport coupled proton transport
q	0022904	biological_process	respiratory electron transport chain
q	0032981	biological_process	mitochondrial respiratory chain complex I assembly
q	0045271	cellular_component	respiratory chain complex I
q	0048039	molecular_function	ubiquinone binding
r	0003954	molecular_function	NADH dehydrogenase activity
r	0005743	cellular_component	mitochondrial inner membrane
r	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
r	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
r	0009060	biological_process	aerobic respiration
r	0022904	biological_process	respiratory electron transport chain
r	0032981	biological_process	mitochondrial respiratory chain complex I assembly
r	0045271	cellular_component	respiratory chain complex I
r	1902600	biological_process	proton transmembrane transport
s	0005739	cellular_component	mitochondrion
s	0005758	cellular_component	mitochondrial intermembrane space
s	0022904	biological_process	respiratory electron transport chain
s	0045271	cellular_component	respiratory chain complex I
t	0005743	cellular_component	mitochondrial inner membrane
t	0005758	cellular_component	mitochondrial intermembrane space
t	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
t	0022904	biological_process	respiratory electron transport chain
t	0045271	cellular_component	respiratory chain complex I
t	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGLDSLDQVEIIMAM

Chain	Residue	Details
O	ASP107-MET122

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site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DIDAEKLMCpqEI

Chain	Residue	Details
O	ASP132-ILE144

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site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiACKlCEaVCP

Chain	Residue	Details
H	CYS113-PRO124
H	CYS152-PRO163

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site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHRGtEKLiEyK

Chain	Residue	Details
C	LEU122-LYS133

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site_id	PS00542
Number of Residues	22
Details	COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREiwDMFgvffanHpdlRrIL

Chain	Residue	Details
D	GLU167-LEU188

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site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCYherlsvaGnCRmC

Chain	Residue	Details
G	PRO61-CYS78

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site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDqGGeCdLQ

Chain	Residue	Details
G	CYS128-GLN140

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site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIqCtRCIrF

Chain	Residue	Details
G	ARG175-PHE185

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site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALIES

Chain	Residue	Details
B	GLY200-SER215

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site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGqCtPCReG

Chain	Residue	Details
B	GLU377-GLY388

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site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQpIaDALKLFtKE

Chain	Residue	Details
r	GLY44-GLU59

---

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLTEGEseLVs.G

Chain	Residue	Details
r	PRO197-GLY210

---

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DklFTlieveCLGaCvnAP

Chain	Residue	Details
E	ASP166-PRO184

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site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GcDRIVPVDIYvPgCPP

Chain	Residue	Details
I	GLY219-PRO235

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI16
Number of Residues	1125
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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