9CCV

Crystal structure of human respiratory syncytial virus NS1 bound to human MED25 ACID

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Non-structural protein 1	polymer	141	15776.2	1	UniProt (E0WLW8) Pfam (PF03438) UniProt (by SIFTS) (P0DOE9)	Human respiratory syncytial virus A	Non-structural protein 1C
2	B (B)	Mediator of RNA polymerase II transcription subunit 25	polymer	185	20971.2	1	UniProt (Q71SY5) Pfam (PF11232)	Homo sapiens (human)	Activator interaction domain-containing protein 1,Activator-recruited cofactor 92 kDa component,ARC92,Mediator complex subunit 25,p78
3	C, D (A, B)	water	water		18.0	33	Chemie (HOH)

Sequence modifications

A: 1 - 139 (UniProt: E0WLW8)

PDB	External Database	Details
Gly -1	-	expression tag
His 0	-	expression tag

B: 389 - 543 (UniProt: Q71SY5)

PDB	External Database	Details
Met 359	-	initiating methionine
Gly 360	-	expression tag
Ser 361	-	expression tag
Ser 362	-	expression tag
His 363	-	expression tag
His 364	-	expression tag
His 365	-	expression tag
His 366	-	expression tag
His 367	-	expression tag
His 368	-	expression tag
Ser 369	-	expression tag
Ser 370	-	expression tag
Gly 371	-	expression tag
Leu 372	-	expression tag
Val 373	-	expression tag
Pro 374	-	expression tag
Arg 375	-	expression tag
Gly 376	-	expression tag
Ser 377	-	expression tag
His 378	-	expression tag
Ile 379	-	expression tag
Glu 380	-	expression tag
Asn 381	-	expression tag
Leu 382	-	expression tag
Tyr 383	-	expression tag
Phe 384	-	expression tag
Gln 385	-	expression tag
Gly 386	-	expression tag
His 387	-	expression tag
Met 388	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	36747.5
All*	Total formula weight	36747.5

*Water molecules are not included.