9CB1
Cryo-EM Structure of the Human Neutralizing Antibody 5-1 in Complex with Prefusion Human Metapneumovirus F Glycoprotein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | 5-1 Fab Heavy Chain Variable Domain | polymer | 219 | 23171.0 | 3 | Homo sapiens (human) | ||
| 2 | D, E, F (D, E, F) | 5-1 Fab Light Chain Variable Domain | polymer | 214 | 23586.1 | 3 | Homo sapiens (human) | ||
| 3 | G, H, I (G, H, I) | Fusion glycoprotein F0 | polymer | 551 | 60489.9 | 3 | UniProt (H6X1Z1) Pfam (PF00523) UniProt (by SIFTS) (Q8B9P0) | human metapneumovirus (hMPV) | F-DsCavEs2-IPDS |
| 4 | J, K, L (J, K, L) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) |
Sequence modifications
G, H, I: 1 - 490 (UniProt: H6X1Z1)
| PDB | External Database | Details |
|---|---|---|
| Cys 84 | Val 84 | engineered mutation |
| Arg 100 | Gln 100 | engineered mutation |
| Arg 101 | Ser 101 | engineered mutation |
| Cys 110 | Leu 110 | engineered mutation |
| Cys 127 | Thr 127 | engineered mutation |
| Cys 140 | Ala 140 | engineered mutation |
| Cys 147 | Ala 147 | engineered mutation |
| Cys 153 | Asn 153 | engineered mutation |
| Pro 185 | Ala 185 | engineered mutation |
| Lys 219 | Leu 219 | engineered mutation |
| Ile 231 | Val 231 | engineered mutation |
| Cys 249 | Ala 249 | engineered mutation |
| Cys 322 | Asn 322 | engineered mutation |
| Cys 365 | Thr 365 | engineered mutation |
| Gln 453 | Glu 453 | engineered mutation |
| Cys 463 | Val 463 | engineered mutation |
| Gly 491 | - | expression tag |
| Gly 492 | - | expression tag |
| Gly 493 | - | expression tag |
| Ser 494 | - | expression tag |
| Gly 495 | - | expression tag |
| Tyr 496 | - | expression tag |
| Ile 497 | - | expression tag |
| Pro 498 | - | expression tag |
| Glu 499 | - | expression tag |
| Ala 500 | - | expression tag |
| Pro 501 | - | expression tag |
| Arg 502 | - | expression tag |
| Asp 503 | - | expression tag |
| Gly 504 | - | expression tag |
| Gln 505 | - | expression tag |
| Ala 506 | - | expression tag |
| Tyr 507 | - | expression tag |
| Val 508 | - | expression tag |
| Arg 509 | - | expression tag |
| Lys 510 | - | expression tag |
| Asp 511 | - | expression tag |
| Gly 512 | - | expression tag |
| Glu 513 | - | expression tag |
| Trp 514 | - | expression tag |
| Val 515 | - | expression tag |
| Leu 516 | - | expression tag |
| Leu 517 | - | expression tag |
| Ser 518 | - | expression tag |
| Thr 519 | - | expression tag |
| Phe 520 | - | expression tag |
| Leu 521 | - | expression tag |
| Gly 522 | - | expression tag |
| Arg 523 | - | expression tag |
| Ser 524 | - | expression tag |
| Leu 525 | - | expression tag |
| Glu 526 | - | expression tag |
| Val 527 | - | expression tag |
| Leu 528 | - | expression tag |
| Phe 529 | - | expression tag |
| Gln 530 | - | expression tag |
| Gly 531 | - | expression tag |
| Pro 532 | - | expression tag |
| Gly 533 | - | expression tag |
| His 534 | - | expression tag |
| His 535 | - | expression tag |
| His 536 | - | expression tag |
| His 537 | - | expression tag |
| His 538 | - | expression tag |
| His 539 | - | expression tag |
| His 540 | - | expression tag |
| His 541 | - | expression tag |
| Ser 542 | - | expression tag |
| Ala 543 | - | expression tag |
| Trp 544 | - | expression tag |
| Ser 545 | - | expression tag |
| His 546 | - | expression tag |
| Pro 547 | - | expression tag |
| Gln 548 | - | expression tag |
| Phe 549 | - | expression tag |
| Glu 550 | - | expression tag |
| Lys 551 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 321741.0 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1273.2 | |
| All* | Total formula weight | 323014.2 |
