9CAQ
Cryo-EM structure of a human MCM2-7 double hexamer formed from independently loaded MCM2-7 single hexamers
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | 2, A | DNA replication licensing factor MCM2 | polymer | 904 | 102034.1 | 2 | UniProt (P49736) In PDB | Homo sapiens (human) | Minichromosome maintenance protein 2 homolog,Nuclear protein BM28 |
| 2 | 3, B | DNA replication licensing factor MCM3 | polymer | 808 | 91110.9 | 2 | UniProt (P25205) In PDB | Homo sapiens (human) | DNA polymerase alpha holoenzyme-associated protein P1,P1-MCM3,RLF subunit beta,p102 |
| 3 | 4, C | DNA replication licensing factor MCM4 | polymer | 863 | 96702.9 | 2 | UniProt (P33991) In PDB | Homo sapiens (human) | CDC21 homolog,P1-CDC21 |
| 4 | 5, D | DNA replication licensing factor MCM5 | polymer | 737 | 82678.9 | 2 | UniProt (P33992) In PDB | Homo sapiens (human) | CDC46 homolog,P1-CDC46 |
| 5 | 6, E | DNA replication licensing factor MCM6 | polymer | 821 | 93010.3 | 2 | UniProt (Q14566) In PDB | Homo sapiens (human) | p105MCM |
| 6 | 7, F | DNA replication licensing factor MCM7 | polymer | 722 | 81684.1 | 2 | UniProt (P33993) In PDB | Homo sapiens (human) | CDC47 homolog,P1.1-MCM3 |
| 7 | O | DNA (44-MER) | polymer | 44 | 13546.9 | 1 | Saccharomyces cerevisiae | ||
| 8 | S | DNA (44-MER) | polymer | 44 | 13528.8 | 1 | Saccharomyces cerevisiae | ||
| 9 | A, C, D, E, 2... | ZINC ION | non-polymer | 65.4 | 10 | Chemie (ZN) | |||
| 10 | 7, A, D, E, 2... | MAGNESIUM ION | non-polymer | 24.3 | 9 | Chemie (MG) | |||
| 11 | A, 2 | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 12 | 7, B, D, E, F... | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 8 | Chemie (ADP) |
Sequence modifications
4, C: 1 - 863 (UniProt: P33991)
5, D: 1 - 734 (UniProt: P33992)
7, F: 1 - 719 (UniProt: P33993)
| PDB | External Database | Details |
|---|---|---|
| Met 650 | Leu 650 | variant |
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 1121518.0 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 5304.8 | |
| All* | Total formula weight | 1126822.8 |
